岳峰 (M.D., Ph.D.), 海南大学生物医学工程学院教授、博士研究生导师。首都医科大学神经病学专业医学博士、临床医学专业博士后。北京大学光华管理学院高级管理人员工商管理硕士。1994-2003年在新疆医科大学第一附属医院神经内科从事临床诊疗、教学与科研工作，历任主治医师，讲师，副主任医师，副教授。2008-2020年在首都医科大学宣武医院/北京市老年病医疗研究中心工作，历任副主任医师、副研究员、研究员。
长期从事神经系统疾病临床诊疗、基础与转化医学研究工作。参与建立了国内早期获得aaalac国际资质认证的专业灵长类动物实验室，负责实验技术平台运营管理。探索实践了基于人类疾病灵长类动物模型及其灵长类动物实验平台的转化医学研究与新药研发服务模式，拓展了多项与国内外新药研发机构、生物技术公司以及大学、科研院所的研究合作。曾在美国威斯康星国家灵长类研究中心及制药企业等机构学习培训。
当前主要工作是开展中枢神经系统疾病的基础与转化医学研究，以及基于非人灵长类模式动物的脑科学/转化医学研究条件支持平台的运行。
研究方向：
1）神经退行性疾病（阿尔茨海默病、帕金森氏病）发病学研究。应用系统性、多维尺度方法开展神经退行性疾病早期发病与演化机制的研究。
2）中枢神经系统疾病神经功能重建研究。基于神经系统疾病拟临床灵长类动物模型以及微生理系统仿真模型，开展神经功能重建研究。
课题、专利与奖项：
主持国家重点研发计划“干细胞及转化研究”重点专项”神经干细胞在重大神经疾病猴模型中的临床前评估”课题；“十二五”国家高技术研究发展计划 (863计划)“代谢类重大疾病灵长类模型的研发”课题以及国家自然科学基金面上项目。参与科技创新2030-“脑科学与类脑研究”重大项目”脑疾病模型猴制备与疾病早期诊断指标建立”课题。获授权发明专利9项，已受理并进入实审的发明专利、实用新型专利16项；获省级科学技术奖2项。
学术论文（*为通讯作者）：
1. Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue*. Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co-Oligomerized with β-Amyloid 1-42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids. Advanced Science. 2026 Jan 22:e16837.
2. Huang X, Zhu X, Fu F, Song J, Zeng J, Huang S, Yue F*. Multi-omics analysis of plasma and CSF in spontaneous diabetic cynomolgus monkeys: Unravelling and validating the key molecular markers that predict the preclinical pathological formation of Alzheimer's disease. Comput Biol Med. 2025;196(Pt B):110849.
3. Zhang Yuling, Liang Caiyan, Weng Miaorong, Zhang Zhouquan, Zhang Lin, Jiang Xue, Yue Feng*. Intestinal alterations of mucosal barrier integrity, motility and enteric nerve in cynomolgus monkey model of Parkinson's disease [J]. Exp Neurol, 2025, 389: 115256.
4. Lin Zhang, Jin Yan, Shunjie Song, Yong Yang, Shouyan Li, Junzhen Song, Miaorong Weng, Caiyan Liang, Feng Yue*. Detection of anxiety and depression-like behavior and intra-brain pathological markers in Parkinsonian cynomolgus monkeys [J]. Exp Neurol, 2025, 389: 115242.
5. He Zhengxiao, Zhang Wenchang, Chen Ping, Li Siyao, Tao Min, Yue Feng, Hong Wei, Feng Su, Jing Naihe. Amyloid-beta oligomers drive amyloid deposit and cascaded tau pathology of Alzheimer's disease in aged brains of non-human primates [J]. J Genet Genomics, 2025.
6. Xinxin Huang, Shanshan Huang, Fangyan Fu, Junzhen Song, Yuling Zhang, Feng Yue*. Characterization of preclinical Alzheimer’s disease model: spontaneous type 2 diabetic cynomolgus monkeys with systemic pro-inflammation,positive biomarkers and developing AD-like pathology. Alzheimers Research & Therapy, 2024, 16(1):52.
7. Jiajun Deng, Bin Liu, Qian Tao, Yanyu Luo, Yi Zhu, Xinxin Huang , Feng Yue*. The co-oligomers of Aβ42 and human islet amyloid polypeptide exacerbate neurotoxicity and Alzheimer-like pathology at cellular level. Neuroscience.2024,S0306-4522(24)00155-6
8. Yang Yong, Liu Qingsu, Yue Feng*. Glycemic Response in Nonhuman Primates Fed Gluten-Free Rice Cakes Enriched with Soy, Pea, or Rice Protein and Its Correlation with Nutrient Composition. Nutrients. 2024; 16(2):234.
9. Chaoyang Tian, Qunhui Yang, Haizhou Lv, Feng Yue*. Integrative analysis of gut microbiota and fecal metabolites in cynomolgus monkeys with spontaneous type 2 diabetes mellitus[J]. Microbial Pathogenesis, 2024: 107228
10. Chaoyang Tian, Qunhui Yang, Haizhou Lv, Feng Yue*. Characteristics of the Serum Microbiota and Circulating Metabolites in Cynomolgus Monkeys with Spontaneous Type 2 Diabetes Mellitus[J]. Journal of Medical Primatology, 2024, 53(5): e12738.
11. Jiang Xueyan, Zhang Mingkai, Yan Chuyao, Daamen Marcel, Boecker Henning, Yue Feng, Jessen Frank, Hu Xiaochen, Han Ying. Brain Topological Changes in Subjective Cognitive Decline and Associations with Amyloid Stages [J]. Journal of Neuroscience, 2024.
12. Yu Bao, Chaoning Gan, Zuyue Chen, Zhongquan Qi, Zhiqiang Meng, Feng Yue*. Quantification of Non-Motor Symptoms in Parkinsonian Cynomolgus Monkeys. Brain Sciences.2023, 13(8), 1153.
13. Tang L, Xu N, Huang M, Yi W, Sang X, Shao M, Li Y, Hao ZZ, Liu R, Shen Y, Yue F, Liu X, Xu C, Liu S. A primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson's disease. Nat Commun. 2023,14(1):7497.
14. Fan Yang; Xueyan Jiang; Feng Yue; Luyao Wang; Henning Boecker; Ying Han; Jiehui Jiang. Exploring dynamic functional connectivity alterations in the preclinical stage of Alzheimer’s disease: an exploratory study from SILCODE, Journal of Neural Engineering, 2022, 19(1): 016036-016036
15. Su Feng , Ting Zhang, Wei Ke , Yujie Xiao , Zhong Guo , Chunling Lu, Shuntang Li , Zhongxin Guo, Yuanyuan Liu , Guohe Tan , Yingying Chen , Feng Yue , Yousheng Shu, Chunmei Yue and Naihe Jing .The long-term survival and functional maturation of human iNPC-derived neurons in the basal forebrain of cynomolgus monkeys. Life Medicine. 2022, 1(2):196–206.
16. Feng Yue*, Su Feng, Chunling Lu, Ting Zhang, Guoxian Tao, Jing Liu, Chunmei Yue, Naihe Jing. Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer’s disease in nonhuman primates. iScience 2021, 24(10), 103207.
17. Jian-Jun Guo, Feng Yue, Dong-Yan Song, Luc Bousset, Xin Liang , Jing Tang, Lin Yuan, Wen Li, Ronald Melki, Yong Tang, Piu Chan, Chuang Guo, Jia-Yi Li. Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis. Cell Death Dis. 2021,12(1):81.
18. Yan Sun, Chuang Guo, Lin Yuan, Wen Li, Zhan-You Wang, Feng Yue*, Jia-Yi Li. Cynomolgus Monkeys with spontaneous Type-2-Diabetes-Mellitus-like pathology develop alpha-synuclein alterations reminiscent of prodromal Parkinson's Disease and related diseases. Front Neurosci. 2020, 14:63.
招生需求：
招收具有生物医学工程、生物学、医学、神经生物学、实验动物、兽医学等相关专业背景硕士与博士研究生，常年招收博士后。
联系方式：fyuee@hainanu.edu.cn
Feng Yue, MD, PhD
Professor and Doctoral Supervisor
School of Biomedical Engineering, Hainan University
Dr. Feng Yue is a Professor and doctoral supervisor at the School of Biomedical Engineering, Hainan University. He earned both his MD and PhD in Neurology from Capital Medical University, Beijing, in 2006, and later completed an Executive Master of Business Administration at the Guanghua School of Management, Peking University, in 2012.
From 1994 to 2003, Dr. Yue worked in the Department of Neurology at the First Affiliated Hospital of Xinjiang Medical University, where he served as an Associate Chief Physician and Associate Professor. He subsequently joined Xuanwu Hospital of Capital Medical University and the Beijing Geriatric Medical Research Center, where he worked from 2008 to 2020 as an Associate Chief Physician and Senior Researcher.
Dr. Yue has extensive experience in the clinical diagnosis and treatment of neurological disorders, as well as in basic and translational neuroscience research. He played a key role in establishing one of China’s earliest professional non-human primate laboratories to obtain AAALAC international accreditation and was responsible for the operation and management of its experimental technology platform. Building on this foundation, he advanced translational research and new drug development models based on disease primate models, fostering collaborations with domestic and international pharmaceutical companies, biotechnology firms, universities, and research institutes. He has also received specialized training at the Wisconsin National Primate Research Center in the United States and within pharmaceutical industry settings.
His current work focuses on basic and translational research on central nervous system diseases, as well as the operation of a brain science and translational medicine support platform based on disease non-human primate models.
Research Interests
• Pathogenesis of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, using systematic and multi-dimensional research approaches.
• Neural function reconstruction in central nervous system disorders, leveraging preclinical primate models and organ-on-a-chip microphysiological systems.
Projects, Patents, Awards, and Teaching
Dr. Yue has led and participated in multiple nationally funded research projects, including the National Key Research and Development Program project “Preclinical Evaluation of Neural Stem Cells in Monkey Models of Major Neurological Diseases,” the National High Technology Research and Development Program (863 Program) key project “Research on Primate Models of Major Metabolic Diseases,” and projects supported by the National Natural Science Foundation of China. He has also contributed to the major STI2030 project “Brain Science and Brain-Inspired Intelligence Research,” specifically in the area of establishing primate models for brain diseases and identifying early diagnostic indicators.
He holds nine authorized invention patents, with an additional twelve patent applications currently under review, and has received two provincial-level science and technology awards. Dr. Yue teaches the undergraduate course “Introduction to Clinical Medicine” and the graduate-level course “Construction and Evaluation of Disease Animal Models.”
Admission Requirements：
M.S./Ph.D. candidates in Biomedical Engineering, Biology, Medicine, Neurobiology, Laboratory Animals, Veterinary Medicine, etc. Postdoctoral positions are open year-round.
Email: fyuee@hainanu.edu.cn
