吴锡龙，教授/研究员，博士生导师。2015年在中国科学院长春应用化学研究所获得博士学位，师从陈学思院士。同年12月至2017年12月在中山大学从事博士后研究工作，2018年1月以“海南大学C类高层次引进人才计划”入职海南大学。现为微纳米智能生物诊疗团队负责人，海南省拔尖人才。研究方向为纳米药物、生物水凝胶、智能微纳米生物机器人与多模态跨尺度成像、类器官三维培养及其在生物医药、再生医学和疾病精准治疗中的应用。相关研究成果以第一或通讯作者发表在Advanced Functional Materials、Biomaterials、Journal of Controlled Release、Chemical Engineering Journal等相关领域国际著名期刊上，获得多项国家授权发明专利，并主持国家自然科学基金面上项目、地区科学基金项目、海南省基础与应用基础研究计划等多项科研项目，同时担任国家科技专家库专家、教育部学位中心学位论文评审专家、教育部科技管理信息系统专家库专家、海南省科技厅专家库专家、海南省知识产权局专家库专家等。
附 团队简介：https://hd.hainanu.edu.cn/shengyi/info/1063/1505.htm
研究领域：
纳米药物与分子影像技术，智能水凝胶，功能高分子与微纳米材料
代表性学术论文：
1、 Li Z, Yu Z, Wu Y, Wu X*, Wan Y, Yan Y, Wang N. Chemical Engineering Journal, 2020, 390(15): 124648. (IF=13.273，中科院JCR工程技术一区)；
2、 Yu Z, Ye D, Zhao J, Wu X*, Wu Y. Chemical Engineering Journal, 2021, 420, 129691. (IF=13.273，中科院JCR工程技术一区)
3、 Wu Y, Li Q, Liu Y, Li Y, Chen Y, Wu X*, Liu X. International Journal of Pharmaceutics, 2021, 605, 120817. (IF=5.875，中科院JCR药学一区)
4、 Wu X, He C, Wu Y, Chen X, Cheng J. Advanced Functional Materials, 2015, 25(43): 6744. (IF=18.8084，中科院JCR工程技术一区)；
5、 Wu X, He C, Wu Y, Chen X. Biomaterials, 2016, 75: 148. (IF=12.479，中科院JCR工程技术一区)；
6、 Wu X, Wu Y, Ye H, Yu S, He C, Chen X. Journal of Controlled Release, 2017, 255: 81. (IF=9.7756，中科院JCR医学一区)；
7、 Wu X, Wu Y, Wang Z, Liu L, Sun C, Chen Y, Wang C. Advanced Healthcare Materials, 2018, 7(11): 1800121. (IF=9.9328，中科院JCR工程技术一区)；
8、 Wu X, Hou J, Li M, Wang J, Kaplan DL, Lu S. Acta Biomaterialia. 2012, 8(6): 2185. (IF=8.9471，中科院JCR工程技术一区)；
部分主持科研项目：
1. 国家自然科学基金面上项目，2021.01-2024.12，主持，在研；
2. 国家自然科学基金地区科学基金项目，2021.01-2024.12，主持，在研；
3. 海南省自然科学基金创新研究团队项目，2022.03-2025.03，主持，在研；
4. 海南省自然科学基金高层次人才项目，2020/01-2022/12，主持，在研；
5. 武汉光电国家研究中心开放基金，2021/01-2023/12，主持，在研；
6. 海南大学C类高层次人才启动基金，2018/01-2022/12，主持，在研；
7. 国家自然科学基金青年科学基金项目，2018/01-2020/12，主持，已结题；
8. 中国博士后基金面上项目，2016/01-2017/12，主持，已结题
招生招聘：
团队招收生物医学工程、化学、材料学、医学、药学或生命科学等相关专业背景的硕博士生、博士后和在编青年博士教师（可直接认定高级职称）。
联系方式： wuxilong@hainanu.edu.cn
Xilong Wu, Ph.D.
Professor, School of Biomedical Engineering, Hainan University
No 58, Renmin Avenue, Haikou, 570228, China
Mobile Phone: (+86)173-8460-0130
Email: xilongwu@foxmail.com
RESEARCH INTERESTS
▶ Nanomedicine, Biological Hydrogels, Biomaterials, Drug Delivery;
▶ Nano-Probes for Multimodal Imaging;
▶ Organic Synthetic Polymer Chemistry, Functional Biodegradable Polymers;
▶ Three-Dimensional Culture of Organoids for Drug Screening, Regenerative Medicine and Precision Medicine;
EDUCATION AND RESEARCH EXPERIENCE
Prof. Dr. Xilong Wu is a Professor in the school of biomedical engineering, Hainan University, China. He received his Ph.D. degree from Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS) in 2015 under the supervision of Prof. Xuesi Chen. Then he worked as a postdoctoral research fellow at Sun Yat-sen University (China), before joining Hainan University in the year 2018. His current research interests mainly include the synthesis of nanometer-sized controlled drug delivery systems and biological hydrogels, the development of functionalized nanoprobes for multimodal imaging and three-dimensional culture of organoids for drug screening, regenerative medicine and precision medicine.
SELECTED PUBLICATIONS
▶ Li Z, Yu Z, Wu Y, Wu X*, Wan Y, Yan Y, Wang N. Self-sterilizing diblock polycation-enhanced polyamidoxime shape-stable blow-spun nanofibers for high-performance uranium capture from seawater. Chemical Engineering Journal, 2020, 390(15): 124648.
▶ Yu Z, Ye D, Zhao J, Wu X*, Wu Y. Photocatalytic anti-biofouling coatings with dynamic surfaces of hybrid metal-organic framework nanofibrous mats for uranium (VI) separation from seawater, Chemical Engineering Journal, 2021, 420, 129691.
▶ Wu Y, Li Q, Liu Y, Li Y, Chen Y, Wu X*, Liu X. Targeting hypoxia for sensitization of tumors to apoptosis enhancement through supramolecular biohybrid bacteria, International Journal of Pharmaceutics, 2021, 605, 120817.
▶ Wu X, He C, Wu Y, Chen X, Cheng J. Nanogel-incorporated physical and chemical hybrid gels for highly effective chemo–protein combination therapy. Advanced Functional Materials, 2015, 25(43): 6744.
▶ Wu X, He C, Wu Y, Chen X. Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials, 2016, 75: 148.
▶ Wu X, Wu Y, Ye H, Yu S, He C, Chen X. Interleukin-15 and cisplatin co-encapsulated thermosensitive polypeptide hydrogels for combined immuno-chemotherapy. Journal of Controlled Release, 2017, 255: 81.
▶ Wu X, Wu Y, Wang Z, Liu L, Sun C, Chen Y, Wang C. A cascade targeting nanocapsule for enhanced photothermal tumor therapy with aid of autophagy inhibition. Advanced Healthcare Materials, 2018, 7(11): 1800121.
▶ Wu X, Hou J, Li M, Wang J, Kaplan DL, Lu S. Sodium dodecyl sulfate-induced rapid gelation of silk fibroin. Acta Biomaterialia. 2012, 8(6): 2185.
SELECTED PAPER TO ACADEMIC CONFERENCES
▶ Wu X, Wu Y, Liu L, Chen Y, "Cellular protease-mediated antitumor drug delivery by hierarchical targeting and pH-sensitive nanosystems", the 2nd International Conference on Nanomedicine, China, Oct 2016, Wuhan, P.R. China.
▶ Wu X, Chu Y, Wu Y, Liu L, Mao H, Chen Y, "Well-defined peptide-conjugated intracellular-acidity-sensitive nanoassemblies for tumor-targeted anticancer drug delivery", 4th Symposium on Innovative Polymers for Controlled Delivery (SIPCD), Sep 2016, Suzhou, P.R. China.
▶ Wu X, He C, Wu Y, Chen X, "Schiff's base cross-linked in situ hydrogels for localized and sustained delivery of anticancer drugs", 2015 National Polymer Academic Report, Oct 2015, Suzhou, P.R. China.
▶ Wu X, He C, Chen X, "Injectable synthetic polypeptide-based hydrogels for biomedical applications", International Symposium on Translational Nanomedicine, Jan 2015, Guangzhou, P.R. China.
▶ Wu X, He C, Chen X, "In situ cross-linking hybrid hydrogels based on naturally-derived polysaccharides and protein", 3rd International Symposium on Polymer Ecomaterials (PEM2014), Aug 2014, Kunming, P.R. China.
▶ Wu, X, Mao L, Lu S, "Preparation and Mechanism of Injectable Silk Hydrogel", The 9th World Biomaterials Congress (WBC), Jun, 2012, Chengdu, P.R. China.
SELECTED PATENTS
▶ China Authorized Patent No. CN 104645348 B: Synthesis and preparation of a kind of novel hydrogel.
▶ China Authorized Patent No. CN 104628885 B: Preparation of a modified dextran-based micelle or drug-carrying nanogel.
▶ China Authorized Patent No. CN 102516777 B: A kind of preparing method of silk fibroin aqueous solution.
▶ China Authorized Patent No. CN 102220017 B: A novel injectable silk fibroin hydrogel and its preparation process and application.
▶ China Authorized Patent No. CN 110846739 B: Design and preparation of anti-shrinkage and antibacterial nanocomposite fibers for extracting uranium from seawater.
▶ China Authorized Patent No. CN 113046857 B: A preparation method of adsorbents with self-renewing antifouling coatings for uranium extraction from seawater.
FUNDING
▶ General Program of National Natural Science Foundation of China (Grant No. 52073077), Period: 2021.01-2024.12;
▶ Regional Program of National Natural Science Foundation of China (Grant No. 22065011), Period: 2021.01-2024.12;
▶ Youth Program of National Natural Science Foundation of China (Grant No. 51703256), Period: 2018.01-2020.12;
▶ Hainan Provincial Natural Science Foundation of China for High-level Talents (Grant No. 2019RC125), Period: 2020.01-2022.12;
▶ Hainan Provincial Natural Science Foundation of China for Scientific Research Innovation Team, Period: 2022.03-2025.03;
▶ Open Project Program of Wuhan National Laboratory for Optoelectronics (Grant NO. 2020WNLOKF020), Period: 2021.01-2023.12;
▶ The Start-up Scientific Research Foundation from Hainan University (Grant No. KYQD(ZR)1828), Period: 2018.01-2022.12;
▶ China Postdoctoral Science Foundation (Grant No. 2016M602578), Period: 2016.01-2017.12;
Recruitment and Qualifications
Recruiting Master/Doctoral Students, Postdoctoral Researchers and Faculty Members in Biomedical Engineering, Chemistry, Materials Science, Medicine, Pharmacy, Life Sciences or Other Related Majors.
