余祥（博士），河南信阳人，教授，博士/硕士生导师，湖北省楚天学者，第十届中国免疫学会“青年学者奖”获得者，海南省优青。2013年毕业于武汉科技大学医学院临床医学专业，获医学学士学位；2019年毕业于华中科技大学武汉光电国家研究中心生物医学工程专业，获工学博士学位，同年就职于三峡大学医学院（高聘副教授），2021年获评三峡大学“优秀教师”，以第一指导老师指导本科生获国家级和省级奖励各4项，市级和校级各1项；2023年2月入职海南大学生物医学工程学院，任高聘教授，2026年3月，晋升教授。主持国家自然科学基金面上项目、青年基金及海南省自然科学基金优秀青年基金项目。以第一作者或通讯作者（末位）在Nature Communications、Light: Science & Applications、Journal of Nanobiotechnology等期刊发表论文20余篇，其中ESI高被引论文2篇。
主要研究方向：
1) 免疫调控与治疗：聚焦肿瘤免疫治疗、神经免疫调控及慢性疾病的免疫调节机制，探索从基础免疫稳态到疾病干预的新策略。
2) 多模态成像与医学图像处理：整合多模态成像可视化技术与医学图像处理方法，结合人工智能实现疾病的精准诊断与临床评估。
代表性论文：
1) Xiang Yu#, Yanfeng Dai#, Yifan Zhao, Shuhong Qi, Lisen Lu, Qingming Luo, Zhihong Zhang*. Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response. Nature Communications, 2020, 11(1): 1110.（IF=15.7，ESI高被引论文）
2) Xiang Yu, Lu Chen, Jianqiao Liu, Bolei Dai, Guoqiang Xu, Guanxin Shen, Qingming Luo*, Zhihong Zhang*. Immune Modulation of Liver Sinusoidal Endothelial Cells by Melittin Nanoparticles Suppresses Liver Metastasis. Nature Communications, 2019, 10(1): 574.（IF=15.7）
3) Ming Hu#, Yingying Wan#, Jiakang Chen#, Chengwei Zhang, Shuze Li, Bingbing Shan, Ling Wu*, Xiang Yu*. Modulation of endothelial-to-mesenchymal transition via NRP-1 targeting with melittin attenuates pulmonary fibrosis. Materials Today Bio, 2025, 102659.（IF=10.2）
4) Ni Yang, Miaomiao Li, Ling Wu, Yinhong Song, Shi Yu, Yingying Wan, Wenjing Cheng, Baoye Yang, Xiaoqin Mou, Hong Yu, Jing Zheng, Xinzhi Li*, and Xiang Yu*. Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis. Journal of Nanobiotechnology, 2023, 21(1): 13.（IF=12.6，ESI高被引论文）
5) Xiang Yu#*, Siyu Jia#, Shi Yu#, Yaohui Chen, Chengwei Zhang, Haidan Chen* , Yanfeng Dai*. Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies. Journal of Nanobiotechnology, 2023, 21(1): 454.（IF=12.6）
6) Yanfeng Dai#, Xiang Yu#, Yifan Zhao, Jianshuang Wei, Dong Lin, Jialu Wang, Ren Zhang, Xuenan Yuan, Sanmu Li, Songlin Huang, Qian Liu*, Zhihong Zhang*. Targeted Modulation of the Meningeal Lymphatic Reverse Pathway for Immunotherapy of Breast Cancer Brain Metastases. ACS Nano, 2025, 19(4): 4830–4844.（IF=16.1）
7) Yanfeng Dai#, Xiang Yu#, Jianshuang Wei#, Fanxin Zeng, Yiran Li, Xiaoquan Yang, Qingming Luo*, Zhihong Zhang*. Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles. Light: Science & Applications. 2020, 9(1): 164.（IF=23.4）
主持科研项目：
1) 海南省自然科学基金优秀青年基金项目，2026/03-2029/02，30万元，主持。
2) 国家自然科学基金面上项目，2025/01-2028/12，48万元，主持。
3) 国家自然科学基金青年科学基金项目，2022/01-2024/12，30万元，主持。
4) 湖北省自然科学基金（面上项目），2020/03-2022/03，主持。
5) 肿瘤微环境与免疫治疗湖北省重点实验室开放基金，2023/09-2025/09，主持。
6) 湖北省胃肠癌精准防治临床医学研究中心开放基金，2022/09-2024/09，主持。
招生需求：
招收生物信息学、免疫学、生物医学工程、生物技术、药学及医学检验等相关专业硕士生、博士生、博士后。
联系方式：yuxiang@hainanu.edu.cn
Basic Information
Xiang Yu, Ph.D.
Professor and Doctoral Supervisor, School of Biomedical Engineering, Hainan University. He currently serves as the principal investigator for six research projects, including both the General Program and the Youth Program of the National Natural Science Foundation of China, as well as the Excellent Young Scientists Fund of the Natural Science Foundation of Hainan Province. He has published over 20 high-impact SCI papers as first or corresponding author in journals such as Nature Communications (featured as Editor's Highlight and listed as an ESI Highly Cited Paper), Light: Science & Applications, ACS Nano, and Journal of Nanobiotechnology.
Research Interests
1) Immune Modulation and Intervention: Focusing on tumor immunotherapy, neuroimmune regulation, and immunomodulatory mechanisms in chronic diseases, exploring novel strategies from fundamental immune homeostasis to disease intervention.
2) Multimodal Imaging and Medical Image Processing: Integrating multimodal imaging visualization techniques with medical image processing methods, combined with artificial intelligence to achieve precision diagnosis and clinical evaluation of diseases.
Awards and Honors
1) Chutian Scholar of Hubei Province
2) Winner of the 10th Chinese Society of Immunology “Young Investigator Award”
Representative Publications (* indicates corresponding author)
1) Xiang Yu#, Yanfeng Dai#, Yifan Zhao, Shuhong Qi, Lisen Lu, Qingming Luo, Zhihong Zhang*. Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response. Nature Communications, 2020, 11(1): 1110. (IF=15.7, ESI Highly Cited Paper)
2) Xiang Yu, Lu Chen, Jianqiao Liu, Bolei Dai, Guoqiang Xu, Guanxin Shen, Qingming Luo*, Zhihong Zhang*. Immune Modulation of Liver Sinusoidal Endothelial Cells by Melittin Nanoparticles Suppresses Liver Metastasis. Nature Communications, 2019, 10(1): 574. (IF=15.7)
3) Ming Hu#, Yingying Wan#, Jiakang Chen#, Chengwei Zhang, Shuze Li, Bingbing Shan, Ling Wu*, Xiang Yu*. Modulation of endothelial-to-mesenchymal transition via NRP-1 targeting with melittin attenuates pulmonary fibrosis. Materials Today Bio, 2025, 102659. (IF=10.2)
4) Ni Yang, Miaomiao Li, Ling Wu, Yinhong Song, Shi Yu, Yingying Wan, Wenjing Cheng, Baoye Yang, Xiaoqin Mou, Hong Yu, Jing Zheng, Xinzhi Li*, and Xiang Yu*. Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis. Journal of Nanobiotechnology, 2023, 21(1): 13. (IF=12.6, ESI Highly Cited Paper)
5) Xiang Yu#*, Siyu Jia#, Shi Yu#, Yaohui Chen, Chengwei Zhang, Haidan Chen* , Yanfeng Dai*. Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies. Journal of Nanobiotechnology, 2023, 21(1): 454. (IF=12.6)
Teaching Experience
Primarily teaches Biomedical Statistics, Human Anatomy and Physiology, Techniques and Advances in Medical Immunology, Experimental Design and Statistical Analysis, and Modern Statistical Methods to undergraduate, master’s, and doctoral students.
