余祥（博士），教授（高聘），湖北省楚天学者，第十届中国免疫学会“青年学者奖”获得者。2013年毕业于武汉科技大学医学院临床医学专业，获医学学士学位；2019年毕业于华中科技大学武汉光电国家研究中心生物医学工程专业，获工学博士学位，同年就职于三峡大学医学院（校聘副教授），2021年获评三峡大学“优秀教师”，以第一指导老师指导本科生获得国家级和省级奖励各4项，市级和校级各1项；2023年2月入职海南大学生物医学工程学院，加入免疫调控与成像团队（负责人张智红教授）。
主要研究方向：
1）慢性疾病的免疫调节与多模态成像可视化
2) 区域免疫器官互作研究
近5年学术论文：
1) Xiang Yu1, Yanfeng Dai1, Yifan Zhao, Shuhong Qi Lisen Lu, Qingming Luo, Zhihong Zhang*. Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response. Nature Communications, 2020, 11(1), 1-14.
2) Xiang Yu, Lu Chen, Jianqiao Liu, Bolei Dai, Guoqiang Xu, Guanxin Shen, Qingming Luo*, Zhihong Zhang*. Immune Modulation of Liver Sinusoidal Endothelial Cells by Melittin Nanoparticles Suppresses Liver Metastasis. Nature Communications, 2019, 10(1): 574.
3) Yanfeng Dai1, Xiang Yu1, Jianshuang Wei1, Fanxin Zeng, Yiran Li, Xiaoquan Yang, Qingming Luo*, Zhihong Zhang*. Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles. Light: Science & Applications. 2020, 9: 164.
4) Ni Yang, Miaomiao Li, Ling Wu, Yinhong Song, Shi Yu, Yingying Wan, Wenjing Cheng, Baoye Yang, Xiaoqin Mou, Hong Yu, Jing Zheng, Xinzhi Li*, and Xiang Yu*. Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis. Journal of Nanobiotechnology, 2023, 21(1): 1-20.
5) Xiang Yu1*, Siyu Jia1, Shi Yu1, Yaohui Chen, Chengwei Zhang, Haidan Chen* , Yanfeng Dai*. Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies. Journal of Nanobiotechnology, 2023, 21(1): 454.
6) Wenjing Cheng, Xiangbai Wu, Shi Yu, Chengwei Zhang, Yinhong Song, Xinzhi Li, Xiang Yu*. Biomimetic nanoplatform with selectively positioned indocyanine green for accurate sentinel lymph node imaging. Nanoscale, 2023, 15(47): 19168-19179.
7) Gan Zhang, Wenjing Cheng, Ni Yang, Baoye Yang, Shi Yu, Jing Zheng, Miaomiao Li, Yaling Fu, Xinzhi Li, Yinhong Song, Zhihong Zhang*, Xiang Yu*. Peptide-decorated Artificial Erythrocyte Microvesicles Endowed with Lymph Node Targeting Function for Drug Delivery. Advanced Therapeutics, 2023: 2200236.
8) Jing Zheng, Ni Yang, Yingying Wan, Wenjing Cheng, Gan Zhang, Shi Yu, Baoye Yang, Xinyu Liu, Xingyan Chen, Xueliang Ding, Ling Wu*, Xiang Yu*. Celastrol-loaded Biomimetic Nanodrug Ameliorates APAP-induced Liver Injury through Modulating Macrophage Polarization. Journal of Molecular Medicine, 2023, 101(6): 699-716.
9) 杨梓萌, 程文静, 余祥*. 新型纳米递送系统在药物诱导肿瘤细胞焦亡中的应用.中国肿瘤生物治疗杂志, 2022.（专家论坛）
10) Baoye Yang, Decheng Wang, Shi Yu, Chengwei Zhang, Jing Ai, Xiang Yu*. Breaking CHIPS-Mediated immune evasion with tripterin to promote neutrophil chemotaxis against MRSA infection. International Immunopharmacology, 2024, 129: 111597.
11) Shiqi Luo, Xinghua Meng, Jing Ai, Zhihong Zhang, Yanfeng Dai*, Xiang Yu*. Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Monobenzone-Induced Vitiligo in Mice. International Journal of Molecular Sciences, 2024, 25(6): 3411.
12) Jing Zheng, Qiulin Yuan, Cao Zhou, Weifeng Huang, Xiang Yu*. Mitochondrial stress response in drug-induced liver injury. Molecular Biology Reports, 2021.48(10), 6949-6958.
主持科研项目：
1) 国家自然科学基金面上项目，2025/01-2028/12，在研，主持。
2) 国家自然科学基金青年科学基金项目，2022/01-2024/12，在研，主持。
3) 湖北省自然科学基金（面上项目），2020/03-2022/03，结题，主持。
4) 肿瘤微环境与免疫治疗湖北省重点实验室开放基金，2023/09-2025/09，在研，主持。
5) 湖北省胃肠癌精准防治临床医学研究中心开放基金，2022/09-2024/09，结题，主持。
招生需求:
招收生物信息学、免疫学、生物医学工程、药学及医学检验等相关专业研究生
联系方式：yuxiang@hainanu.edu.cn
Basic Information
Yu Xiang, Ph.D.
Professor and Doctoral Supervisor, School of Biomedical Engineering, Hainan University. He currently serves as the principal investigator for six research projects, including both the General Program and the Youth Program of the National Natural Science Foundation of China. He has published over 16 high-impact SCI papers as first or corresponding author in journals such as Nature Communications (featured as Editor's Highlight and listed as an ESI Highly Cited Paper), Light: Science & Applications, ACS Nano, and Journal of Nanobiotechnology.
Research Interests
(1) Neuroimmune Regulation in Chronic Diseases
(2) Interregional Neuroimmune Organ Interactions
Awards and Honors
(1) Chutian Scholar of Hubei Province
(2) Winner of the 10th Chinese Society of Immunology “Young Investigator Award”
Representative Publications (* indicates corresponding author)
(1) Xiang Yu1, Yanfeng Dai1, Yifan Zhao, Shuhong Qi Lisen Lu, Qingming Luo, Zhihong Zhang*. Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response. Nature Communications, 2020, 11(1), 1-14.
(2) Xiang Yu, Lu Chen, Jianqiao Liu, Bolei Dai, Guoqiang Xu, Guanxin Shen, Qingming Luo*, Zhihong Zhang*. Immune Modulation of Liver Sinusoidal Endothelial Cells by Melittin Nanoparticles Suppresses Liver Metastasis. Nature Communications, 2019, 10(1): 574.
(3) Ni Yang, Miaomiao Li, Ling Wu, Yinhong Song, Shi Yu, Yingying Wan, Wenjing Cheng, Baoye Yang, Xiaoqin Mou, Hong Yu, Jing Zheng, Xinzhi Li*, and Xiang Yu*. Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis. Journal of Nanobiotechnology, 2023, 21(1): 1-20.
(4)Xiang Yu1*, Siyu Jia1, Shi Yu1, Yaohui Chen, Chengwei Zhang, Haidan Chen* , Yanfeng Dai*. Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies. Journal of Nanobiotechnology, 2023, 21(1): 454.
(5) Ming Hu1, Yingying Wan1, Jiakang Chen1, Chengwei Zhang, Shuze Li, Bingbing Shan, Ling Wu*, Xiang Yu*. Modulation of endothelial-to-mesenchymal transition via NRP-1 targeting with melittin attenuates pulmonary fibrosis. Materials Today Bio, 2025, 102659.
(6) Yanfeng Dai1, Xiang Yu1, Jianshuang Wei1, Fanxin Zeng, Yiran Li, Xiaoquan Yang, Qingming Luo*, Zhihong Zhang*. Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles. Light: Science & Applications. 2020, 9: 164.
(7) Yanfeng Dai#,Xiang Yu#, Yifan Zhao, Jianshuang Wei, Dong Lin, Jialu Wang, Ren Zhang, Xuenan Yuan, Sanmu Li, Songlin Huang, Qian Liu*, Zhihong Zhang*. Targeted Modulation of the Meningeal Lymphatic Reverse Pathway for Immunotherapy of Breast Cancer Brain Metastases. ACS Nano, 2025, 19(4): 4830–4844.
Teaching Experience
Primarily teaching Biomedical Statistics, Techniques and Advances in Medical Immunology, Experimental Design and Statistical Analysis, and Modern Statistical Methods to undergraduate, master’s, and doctoral students.
