李向宁，海南大学生物医学工程学院教授，博士生导师，华中科技大学苏州脑空间信息研究院生物平台主任，中国生物医学工程学会类器官与器官芯片分会副主任委员，中国动物学会灵长类专业委员会常委。2007年毕业于华中科技大学，获生物医学工程专业博士学位。2007-2023年于华中科技大学工作，历任讲师、副教授、教授。2010-2012年纽约州立大学布法罗分校做博士后研究，2016年于美国冷泉港实验室做访问学者。2008年获湖北省优秀博士学位论文奖，2017年指导本科生获得湖北省优秀学士论文。
主要研究方向：
1) 神经与血管三维示踪技术；
2) 中枢-外周互作；
3) 神经肿瘤；
4) 多组学技术；
5) 类器官体外模型构建与检测。
主持国家自然科学基金青年基金、面上项目、区域联合重点项目，科技部科技创新2030重大项目，参与了国家自然科学基金重大项目、国家重大科学仪器设备开发专项等项目。
招生专业：
招收神经生物学、生命科学、生物医学工程、化学等相关专业的本科生、硕士及博士研究生；相关研究方向的博士后和教师，隶属脑空间信息学团队（骆清铭团队）。
联系方式：lixiangning@hainanu.edu.cn
代表性文章（*为通讯作者,#为同等贡献）：
2026
Qianqian Li, … Xiangning Li*, Miao Ren*, Single-nucleus transcriptomics uncovers region-specific molecular features underlying selective aging vulnerability of cholinergic neurons, iScience, 2026, 29(11):117778.
Chen Yingying, … Xiangning Li*. Synaptic-level organization of long-range cholinergic circuits in the basal forebrain. Commun Biol (2026). doi.org/10.1038/s42003-026-10786-9
Deng Zhiyu, … Xiangning Li*. Regulation of Neuronal Senescence by Srebf2 and Zmiz1 Reveals Mechanisms of Aging-Related Neurodegeneration, Biology, 2026,15(12): 938
2025
Ding WQ, ... Li X, ... Single-neuron projectome reveals organization of somatosensory ascending pathways in the mouse brain. Neuron. 2025, 113(13):2083-2101.e5.
Wang T, ... Li X, .... Identification of a neural basis for energy expenditure in the mouse arcuate hypothalamus. Neuron. 2025, 113(22):3813-3833.e9.
Gou L, ... Li X, ... Single-neuron projectomes of macaque prefrontal cortex reveal refined axon targeting and arborization. Cell. 2025, 188(14):3806-3822.e24.
Feng Z, Li X, .... A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution. Nature. 2025, 645(8080):448-456.
Zhao Mengting, ... Luo Qingming*, Li Xiangning*, Li Anan*. Molecularly defined cellular atlas of the entire mouse brain with isotropic single-cell resolution. Nat Commun. 2025, 16(1):10167. doi: 10.1038/s41467-025-65238-5. PMID: 41261161.
Luo Xiaoman, …. Li Xiangning*. A Simple Three-Dimensional Compartmentalized Co-Culture Model for Basal Forebrain and Hippocampal Neurons. Biology (Basel). 2025, 14(9):1238. .
Sun Tingting, ... Gong Hui*, Li Xiangning*. Parvalbumin Neurons in the Basal Forebrain Projecting to the Mammillary Nucleus Ameliorate Age-Related Cognitive Decline. Int J Mol Sci. 2025, 26(13):5934.
Sun Tingting, ..., Li Xiangning*, Vulnerability of long-range inputome of basal forebrain in normal aging mice. Front. Aging Neurosci. 2025, 17:1573906.
Zhang Jianping, ... Luo Qingming*, Li Xiangning*. A dorsal subiculum-medial mammillary body pathway for spatial memory. Molecular Psychiatry, 2025, 30, 5045-5057.
Ren Miao, ..., Gong Hui*, Li Xiangning*. Long-range inputome of prefrontal GABAergic interneurons in the Alzheimer's disease mouse. Alzheimers Dement. 2025, 21(2):e14552. .
Chen Jiale, ..., Luo Qingming*, Li Xiangning*. Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways. Brain. 2025, 148(7): 2493-2508.
2024
Mei Yao, ..., Xiangning Li*, Qingming Luo*. From Individual to Population: Circuit Organization of Pyramidal Tract and Intratelencephalic Neurons in Mouse Sensorimotor Cortex. Research (Wash D C). 2024, 7:0470.
Zhixiang Liu, … Xiangning Li*, The cytoarchitectonic landscape revealed by deep learning method facilitated precise positioning in mouse neocortex, Cerebral Cortex, 2024, 34(6), bhae229
Tudi Ayizuohere, ..., Li Xiangning*. Subregion preference in the long-range connectome of pyramidal neurons in the medial prefrontal cortex. BMC Biology, 2024, 22(1):95.
Zhixiang Liu, …, Xiangning Li*. A complementary approach for neocortical cytoarchitecture inspection with cellular resolution imaging at whole brain scale. Front Neuroanat. 2024, 18:1388084.
Feifang Tang, …, Xiangning Li*. Optogenetic Brain-Computer Interfaces. Bioengineering (Basel). 2024, 11(8):821.
Bingqing Ji, …, Xiangning Li*, Streamlined Full-Length Total RNA Sequencing of Paraformaldehyde-Fixed Brain Tissues, International Journal of Molecular Sciences, 2024, 25(12):6504
Shou Qiu, ... Xiangning Li, ..., Whole-brain spatial organization of hippocampal single-neuron projectomes. Science, 2024, 383: eadj9198.
2023年：
Bimin Liu, …, Xiangning Li*, Targeted approaches to delineate neuronal morphology during early development. Frontiers in Cellular Neuroscience, 2023. 17.
Siqi Chen, … Xiangning Li*. Three-dimensional mapping in multi-samples with large-scale imaging and multiplexed post staining. Communications Biology, 2023, 6 (1): 148.
Chen Juan, H…, Xiangning Li*. Cerebral Organoid Arrays for Batch Phenotypic Analysis in Sections and Three Dimensions, International Journal of Molecular Sciences, 2023.24(18): 13903.
Jiaojiao Tian, …, Xiangning Li*, Low-temperature resin embedding of the whole brain for various precise structures dissection, iSicence, 2023, 26(5): 106705
Mei Yao, …Xiangning Li*, Long-range connectome of pyramidal neurons in the sensorimotor cortex, iSicence, 2023, 26(4):106316.
Peilin Zhao, Tao Jiang, Huading Wang, Xueyan Jia, Anan Li, Hui Gong, Xiangning Li*, Upper brainstem cholinergic neurons project to ascending and descending circuits, BMC Biology, 2023, 21: 135
-2022年
Jiaojiao Tian#,..., Xiangning Li*, Qingming Luo*. Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain. PNAS, 2022, 119 (40): e2202536119.
Sun Qingtao, ... Li Xiangning*, Luo Qingming*. Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease. Nature Communications, 2022, 13, 998.
Can Zhou, …, Xiangning Li*, Hui Gong*, Continuous subcellular resolution three-dimensional imaging on intact macaque brain, Science Bulletin, 2022, 67(1): 85-96
Foster, N. N., ... Li Xiangning,.... The mouse cortico-basal ganglia-thalamic network. Nature, 2021 598(7879):188-194.
Munoz-Castaneda, .... Li Xiangning, .... Cellular anatomy of the mouse primary motor cortex. Nature, 2021, 598(7879):159-166.
Peng, H., ..., Li Xiangning, .... Morphological diversity of single neurons in molecularly defined cell types. Nature, 2021, 598(7879):174-181.
Qiuyuan Zhong, …, Xiangning Li, …, Qingming Luo, High-definition imaging using line-illumination modulation microscopy. Nat Methods, 2021, 18 (3): 309-+.
Peng Chen, ...Xiangning Li,..., Prefrontal cortex corticotropin-releasing factor neurons control behavioral style selection under challenging situations, Neuron, 2020, 106, 301-31
Sun Qingtao#, Li Xiangning#, … Luo Qingming, A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex. Nature Neuroscience, 2019, 22:1357-1370.
Li Xiangning#,…, Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons. PNAS, 2018, 115(2): 415-420.
