李向宁，海南大学生物医学工程学院教授，博士生导师，华中科技大学苏州脑空间信息研究院生物平台主任，中国生物医学工程学会类器官与器官芯片分会副主任委员，中国动物学会灵长类专业委员会常委。2007年毕业于华中科技大学，获生物医学工程专业博士学位。2007-2023年于华中科技大学工作，历任讲师、副教授、教授。2010-2012年纽约州立大学布法罗分校做博士后研究，2016年于美国冷泉港实验室做访问学者。2008年获湖北省优秀博士学位论文奖，2017年指导本科生获得湖北省优秀学士论文。

主要研究方向：

介观水平解析神经系统组织规律和病理机制。1)开发适用于大体积生物组织的特异标记和样本处理策略，探索啮齿类、灵长类整体器官结构和组织模式；2)结合显微光学切片成像、光电联合刺激、类器官等技术，在解析学习与记忆的神经环路、退行性疾病机制等。相关工作以第一作者或通讯作者发表于Nature Neuroscience, Nature Communications, PNAS, Science Bulletin等。合作文章发表于Nature, Science, Cell, Nature Methods, Neuron等顶级期刊。

主持国家自然科学基金青年基金、面上项目、区域联合重点项目，科技部科技创新2030重大项目，参与了国家自然科学基金重大项目、国家重大科学仪器设备开发专项等项目。

招生专业：
神经生物学、生命科学、生物医学工程、化学等相关专业

联系方式：lixiangning@hainanu.edu.cn

代表性文章（*为通讯作者,#为同等贡献）：

2025：

Ding WQ, ... Li X, ... Single-neuron projectome reveals organization of somatosensory ascending pathways in the mouse brain. Neuron. 2025, 113(13):2083-2101.e5.

Wang T, ... Li X, .... Identification of a neural basis for energy expenditure in the mouse arcuate hypothalamus. Neuron. 2025, 113(22):3813-3833.e9.

Gou L, ... Li X, ...  Single-neuron projectomes of macaque prefrontal cortex reveal refined axon targeting and arborization. Cell. 2025, 188(14):3806-3822.e24.

Feng Z, Li X, .... A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution. Nature. 2025, 645(8080):448-456.

Zhao Mengting, ... Luo Qingming*, Li Xiangning*, Li Anan*. Molecularly defined cellular atlas of the entire mouse brain with isotropic single-cell resolution. Nat Commun. 2025, 16(1):10167. doi: 10.1038/s41467-025-65238-5. PMID: 41261161.

Luo Xiaoman, Li Jing, Deng Zhiyu, Xu Yali, Li Xixi, Ren Miao*, Li Xiangning*. A Simple Three-Dimensional Compartmentalized Co-Culture Model for Basal Forebrain and Hippocampal Neurons. Biology (Basel). 2025, 14(9):1238. .

Sun Tingting, ... Gong Hui*, Li Xiangning*. Parvalbumin Neurons in the Basal Forebrain Projecting to the Mammillary Nucleus Ameliorate Age-Related Cognitive Decline. Int J Mol Sci. 2025, 26(13):5934.

Sun Tingting, ..., Gong Hui*, Li Xiangning*, Vulnerability of long-range inputome of basal forebrain in normal aging mice. Front. Aging Neurosci. 2025, 17:1573906.

Zhang Jianping, ... He Miao*, Luo Qingming*, Li Xiangning*. A dorsal subiculum-medial mammillary body pathway for spatial memory. Molecular Psychiatry, 2025, 30, 5045-5057.

Ren Miao, ..., Gong Hui*, Li Xiangning*. Long-range inputome of prefrontal GABAergic interneurons in the Alzheimer's disease mouse. Alzheimers Dement. 2025, 21(2):e14552. .

Chen Jiale, ..., Luo Qingming*, Li Xiangning*. Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways. Brain. 2025, 148(7): 2493-2508.

2024：

Mei Yao, ..., Josh Huang*, Hui Gong*, Xiangning Li*, Qingming Luo*. From Individual to Population: Circuit Organization of Pyramidal Tract and Intratelencephalic Neurons in Mouse Sensorimotor Cortex. Research (Wash D C). 2024, 7:0470.

Tudi Ayizuohere, ..., Li Xiangning*. Subregion preference in the long-range connectome of pyramidal neurons in the medial prefrontal cortex. BMC Biology, 2024, 22(1):95.

Zhixiang Liu, Anan Li, Hui Gong, Xiaoquan Yang, Qingming Luo, Zhao Feng, Xiangning Li*, The cytoarchitectonic landscape revealed by deep learning method facilitated precise positioning in mouse neocortex, Cerebral Cortex, 2024, 34(6), bhae229

Zhixiang Liu, Zhao Feng, Guangcai Liu, Anan Li, Hui Gong, Xiaoquan Yang, Xiangning Li*. A complementary approach for neocortical cytoarchitecture inspection with cellular resolution imaging at whole brain scale. Front Neuroanat. 2024, 18:1388084.

Feifang Tang, Feiyang Yan, Yushan Zhong, Jinqian Li, Hui Gong, Xiangning Li*. Optogenetic Brain-Computer Interfaces. Bioengineering (Basel). 2024, 11(8):821.

Bingqing Ji, Jiale Chen, Hui Gong, Xiangning Li*, Streamlined Full-Length Total RNA Sequencing of Paraformaldehyde-Fixed Brain Tissues, International Journal of Molecular Sciences, 2024, 25(12):6504

Shou Qiu, ... Xiangning Li, ..., Whole-brain spatial organization of hippocampal single-neuron projectomes. Science, 2024, 383: eadj9198.

2023年：

Bimin Liu, Yuxiao Li, Miao Ren*, Xiangning Li*, Targeted approaches to delineate neuronal morphology during early development. Frontiers in Cellular Neuroscience, 2023. 17.

Siqi Chen, Guangcai Liu, Anan Li, Zhixiang Liu, Ben Long, Xiaoquan Yang, Hui Gong , Xiangning Li . Three-dimensional mapping in multi-samples with large-scale imaging and multiplexed post staining. Communications Biology, 2023, 6 (1): 148.

Chen Juan, Haihua Ma, Zhiyu Deng, Qingming Luo, Hui Gong, Ben Long*, Xiangning Li*. Cerebral Organoid Arrays for Batch Phenotypic Analysis in Sections and Three Dimensions, International Journal of Molecular Sciences, 2023.24(18): 13903.

Jiaojiao Tian, Yingying Chen, Tao Jiang, Xueyan Jia, Hui Gong, Xiangning Li*, Low-temperature resin embedding of the whole brain for various precise structures dissection, iSicence, 2023, 26(5): 106705

Mei Yao, Ayizuohere Tudi, Tao Jiang, Xu An, Qingtao Sun, Anan Li, Z Josh Huang, Hui Gong, Xiangning Li*, Long-range connectome of pyramidal neurons in the sensorimotor cortex, iSicence, 2023, 26(4):106316.

Peilin Zhao, Tao Jiang, Huading Wang, Xueyan Jia, Anan Li, Hui Gong, Xiangning Li*, Upper brainstem cholinergic neurons project to ascending and descending circuits, BMC Biology, 2023, 21: 135

2022年之前

Jiaojiao Tian#, Miao Ren#, Peilin Zhao#, ..., Xiangning Li*, Qingming Luo*. Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain. PNAS, 2022, 119 (40): e2202536119.

Sun Qingtao, Zhang Jianping, ... Li Xiangning*, Luo Qingming*. Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease. Nature Communications, 2022, 13, 998.

Can Zhou, Xiaoquan Yang, Shihao Wu,..., Xintian Hu*, Xiangning Li*, Hui Gong*, Continuous subcellular resolution three-dimensional imaging on intact macaque brain, Science Bulletin, 2022, 67(1): 85-96

Yang Yang, Jiang Tao, Jia Xueyan, Li Xiangning*, Gong Hui*. Whole-Brain Connectome of GABAergic Neurons in the Mouse Zona Incerta. Neuroscience Bulletin, 2022. doi.org/10.1007/s12264-022-00930-w

Foster, N. N., ... Li Xiangning,.... The mouse cortico-basal ganglia-thalamic network. Nature, 2021 598(7879):188-194.

Munoz-Castaneda, .... Li Xiangning, .... Cellular anatomy of the mouse primary motor cortex. Nature, 2021, 598(7879):159-166.

Peng, H., ..., Li Xiangning, .... Morphological diversity of single neurons in molecularly defined cell types. Nature, 2021, 598(7879):174-181.

Qiuyuan Zhong, Anan Li, Rui Jin, Dejie Zhang, Xiangning Li, Xueyan Jia, Zhangheng Ding, Pan Luo, Can Zhou, Chengyu Jiang, Zhao Feng, Zhihong Zhang, Hui Gong, Jing Yuan, Qingming Luo, High-definition imaging using line-illumination modulation microscopy. Nat Methods, 2021, 18 (3): 309-+.

Peng Chen, ...Xiangning Li,..., Prefrontal cortex corticotropin-releasing factor neurons control behavioral style selection under challenging situations, Neuron, 2020, 106, 301-31

Long Ben, Jiang Tao, Zhang Jianmin, Chen Siqi, Jia Xueyan, Xu Xiaofeng, Luo Qingming, Gong Hui, Li Anan, Li Xiangning*. Mapping the Architecture of Ferret Brains at Single-Cell Resolution. Front. Neurosci. 2020, 14:322.

Ting Luo, Lei Deng, Anan Li, Can Zhou, Shuai Shao, Qingtao Sun, Hui Gong, Xiaoquan Yang, Xiangning Li*，Scalable Resin Embedding Method for Large-Volume Brain Tissues with High Fluorescence Preservation Capacity. iScience, 2020, 23:101717

Duan Zhuonan, Li Anan, Gong Hui, Li Xiangning*.A Whole-brain Map of Long-range Inputs to GABAergic Interneurons in the Mouse Caudal Forelimb Area. Neuroscience Bulletin. 2020. 36, 493-505

Sun Qingtao#, Li Xiangning#, Ren Miao, Zhao Mengting, Zhong Qiuyuan, Ren Yuqi, Luo Pan, Ni Hong, Zhang Xiaoyu, Zhang Chen, Yuan Jing, Li Anan, Luo Minmin, Gong Hui, Luo Qingming, A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex. Nature Neuroscience, 2019, 22:1357-1370.

Li Xiangning#,Yu Bin#, Sun Qingtao, Zhang Yalun, Ren Miao, Zhang Xiaoyan, Li Anan, Yuan Jing, Madisen L., Luo Qingming, Zeng Hongkui, Gong Hui, Qiu Zilong, Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons. PNAS, 2018, 115(2): 415-420.