李向宁，海南大学生物医学工程学院教授，博士生导师，华中科技大学苏州脑空间信息研究院生物平台主任，中国生物医学工程学会类器官与器官芯片分会副主任委员。2007年毕业于华中科技大学，获生物医学工程专业博士学位。2007-2023年于华中科技大学工作，历任讲师、副教授、教授。2010-2012年纽约州立大学布法罗分校做博士后研究，2016年于美国冷泉港实验室做访问学者。2008年获湖北省优秀博士学位论文奖，2017年指导本科生获得湖北省优秀学士论文。
主要研究：
从事神经环路结构、功能与病理机制研究。1)致力于开发适用于大体积生物组织的样本处理策略，探索啮齿类、灵长类整体器官结构和组织模式；2)结合显微光学切片成像、光电联合刺激、类器官等技术，在在介观水平解析学习与记忆的神经环路基础、神经退行性疾病机制等。相关工作以第一作者或通讯作者发表于Nature Neuroscience, Nature Communications, PNAS, Science Bulletin等。合作文章发表于Nature, Nature Methods, Neuron等顶级期刊。
主持国家自然科学基金青年基金、面上项目，科技部科技创新2030重大项目，参与了国家自然科学基金重大项目、国家重大科学仪器设备开发专项等项目。
代表性文章（*为通讯作者,#为同等贡献）：
1. Zhao Peilin, Jiang Tao, Wang Huading, Jia Xueyan, Li Anan, Li Xiangning*, Gong Hui*. Upper brainstem cholinergic neurons project to ascending and descending circuits. BMC biology, 2023, 21(1):135.
2. Yao Mei, Ayizuohere Tudi, Jiang Tao, An Xu, Sun Qingtao, Li Anan+, Huang Z. Josh, Gong Hui*, Li Xiangning*, Long-range connectome of pyramidal neurons in the sensorimotor cortex. iScience, 2023, 26(4):106316.
3. Chen Siqi, Liu Guangcai, Li Anan, Liu Zhixiang, Long Ben, Yang Xiaoquan, Gong Hui, Li Xiangning*, Three-dimensional mapping in multi-samples with large-scale imaging and multiplexed post staining. Commun Biol, 2023, 6(1):148.
4. Tian Jiaojiao, Chen Yingying, Jiang Tao, Jia Xueyan, Gong Hui*, Li Xiangning*, (2023) Low-temperature resin embedding of the whole brain for various precise structures dissection. iScience, 2023, 26(5):106705.
5. Jiaojiao Tian#, Miao Ren#, Peilin Zhao#, Shukang Luo, Yingying Chen, Xiaofeng Xu, Tao Jiang, Qingtao Sun, Anan Li, Hui Gong, Xiangning Li*, Qingming Luo*. Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain. PNAS, 2022, 119 (40): e2202536119.
6. Sun Qingtao, Zhang Jianping, Li Anan, Yao Mei, Liu Guangcai, Chen Siqi, Luo Yue, Wang Zhi, Gong Hui, Li Xiangning*, Luo Qingming*. Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease. Nature Communications, 2022, 13, 998.
7. Can Zhou, Xiaoquan Yang, Shihao Wu, Qiuyuan Zhong, Ting Luo, Anan Li, Guangcai Liu, Qingtao Sun, Pan Luo, Lei Deng, Hong Ni, Chaozhen Tan, Jing Yuan, Qingming Luo, Xintian Hu*, Xiangning Li*, Hui Gong*, Continuous subcellular resolution three-dimensional imaging on intact macaque brain, Science Bulletin, 2022, 67(1): 85-96
8. Y. Zhang, X. Xing, B. Long, Y. Cao, S. Hu, Xiangning Li, Y. Yu, D. Tian, B. Sui, Z. Luo, W. Liu, L. Lv, Q. Wu, J. Dai, M. Zhou, H. Han, Z. F. Fu, H. Gong, F. Bai and L. ZhaoA spatial and cellular distribution of rabies virus infection in the mouse brain revealed by fMOST and single-cell RNA sequencing. Clinical and translational medicine, 2022 12(1):e700.
9. Zhao Peilin, Wang Huading, Li Anan, Sun Qingtao, Jiang Tao, Li Xiangning*, Gong Hui*. The Mesoscopic Connectome of the Cholinergic Pontomesencephalic Tegmentum. Frontiers in neuroanatomy 16:843303.
10. Ma H, et al. (2022) Multiscale Analysis of Cellular Composition and Morphology in Intact Cerebral Organoids. Biology (Basel) 11(9).
11. Yang Yang, Jiang Tao, Jia Xueyan, Li Xiangning*, Gong Hui*. Whole-Brain Connectome of GABAergic Neurons in the Mouse Zona Incerta. Neuroscience Bulletin, 2022. doi.org/10.1007/s12264-022-00930-w
12. Foster, N. N., Barry, J., Korobkova, L., Garcia, L., Gao, L., Becerra, M., Sherafat, Y., Peng, B., Li Xiangning, Choi, J. H., Gou, L., Zingg, B., Azam, S., Lo, D., Khanjani, N., Zhang, B., Stanis, J., Bowman, I., Cotter, K., Cao, C., Yamashita, S., Tugangui, A., Li, A., Jiang, T., Jia, X., Feng, Z., Aquino, S., Mun, H. S., Zhu, M., Santarelli, A., Benavidez, N. L., Song, M., Dan, G., Fayzullina, M., Ustrell, S., Boesen, T., Johnson, D. L., Xu, H., Bienkowski, M. S., Yang, X. W., Gong, H., Levine, M. S., Wickersham, I., Luo, Q., Hahn, J. D., Lim, B. K., Zhang, L. I., Cepeda, C., Hintiryan, H. and Dong, H. W. The mouse cortico-basal ganglia-thalamic network. Nature, 2021 598(7879):188-194.
13. Munoz-Castaneda, R., Zingg, B., Matho, K. S., Chen, X., Wang, Q., Foster, N. N., Li, A., Narasimhan, A., Hirokawa, K. E., Huo, B., Bannerjee, S., Korobkova, L., Park, C. S., Park, Y. G., Bienkowski, M. S., Chon, U., Wheeler, D. W., Li Xiangning, Wang, Y., Naeemi, M., Xie, P., Liu, L., Kelly, K., An, X., Attili, S. M., Bowman, I., Bludova, A., Cetin, A., Ding, L., Drewes, R., D'Orazi, F., Elowsky, C., Fischer, S., Galbavy, W., Gao, L., Gillis, J., Groblewski, P. A., Gou, L., Hahn, J. D., Hatfield, J. T., Hintiryan, H., Huang, J. J., Kondo, H., Kuang, X., Lesnar, P., Li, X., Li, Y., Lin, M., Lo, D., Mizrachi, J., Mok, S., Nicovich, P. R., Palaniswamy, R., Palmer, J., Qi, X., Shen, E., Sun, Y. C., Tao, H. W., Wakemen, W., Wang, Y., Yao, S., Yuan, J., Zhan, H., Zhu, M., Ng, L., Zhang, L. I., Lim, B. K., Hawrylycz, M., Gong, H., Gee, J. C., Kim, Y., Chung, K., Yang, X. W., Peng, H., Luo, Q., Mitra, P. P., Zador, A. M., Zeng, H., Ascoli, G. A., Josh Huang, Z., Osten, P., Harris, J. A. and Dong, H. W. Cellular anatomy of the mouse primary motor cortex. Nature, 2021, 598(7879):159-166.
14. Peng, H., Xie, P., Liu, L., Kuang, X., Wang, Y., Qu, L., Gong, H., Jiang, S., Li, A., Ruan, Z., Ding, L., Yao, Z., Chen, C., Chen, M., Daigle, T. L., Dalley, R., Ding, Z., Duan, Y., Feiner, A., He, P., Hill, C., Hirokawa, K. E., Hong, G., Huang, L., Kebede, S., Kuo, H. C., Larsen, R., Lesnar, P., Li, L., Li, Q., Li Xiangning, Li, Y., Li, Y., Liu, A., Lu, D., Mok, S., Ng, L., Nguyen, T. N., Ouyang, Q., Pan, J., Shen, E., Song, Y., Sunkin, S. M., Tasic, B., Veldman, M. B., Wakeman, W., Wan, W., Wang, P., Wang, Q., Wang, T., Wang, Y., Xiong, F., Xiong, W., Xu, W., Ye, M., Yin, L., Yu, Y., Yuan, J., Yuan, J., Yun, Z., Zeng, S., Zhang, S., Zhao, S., Zhao, Z., Zhou, Z., Huang, Z. J., Esposito, L., Hawrylycz, M. J., Sorensen, S. A., Yang, X. W., Zheng, Y., Gu, Z., Xie, W., Koch, C., Luo, Q., Harris, J. A., Wang, Y. and Zeng, H. Morphological diversity of single neurons in molecularly defined cell types. Nature, 2021, 598(7879):174-181.
15. Qiuyuan Zhong, Anan Li, Rui Jin, Dejie Zhang, Xiangning Li, Xueyan Jia, Zhangheng Ding, Pan Luo, Can Zhou, Chengyu Jiang, Zhao Feng, Zhihong Zhang, Hui Gong, Jing Yuan, Qingming Luo, High-definition imaging using line-illumination modulation microscopy. Nat Methods, 2021, 18 (3): 309-+.
16. Peng Chen, Shihao Lou, Zhao-Huan Huang, Zhenni Wang, Qing-Hong Shan, Yu Wang, Yupeng Yang, Xiangning Li, Hui Gong, Yan Jin, Zhi Zhang, Jiang-Ning Zhou*, Prefrontal cortex corticotropin-releasing factor neurons control behavioral style selection under challenging situations, Neuron, 2020, 106, 301-31
17. Long Ben, Jiang Tao, Zhang Jianmin, Chen Siqi, Jia Xueyan, Xu Xiaofeng, Luo Qingming, Gong Hui, Li Anan, Li Xiangning*. Mapping the Architecture of Ferret Brains at Single-Cell Resolution. Front. Neurosci. 2020, 14:322. doi: 10.3389/fnins.2020.00322
18. Ting Luo, Lei Deng, Anan Li, Can Zhou, Shuai Shao, Qingtao Sun, Hui Gong, Xiaoquan Yang, Xiangning Li*，Scalable Resin Embedding Method for Large-Volume Brain Tissues with High Fluorescence Preservation Capacity. iScience, 2020, 23:101717
19. Duan Zhuonan, Li Anan, Gong Hui, Li Xiangning*. A Whole-brain Map of Long-range Inputs to GABAergic Interneurons in the Mouse Caudal Forelimb Area. Neuroscience Bulletin. 2020. 36, 493-505
20. Sun Qingtao#, Li Xiangning#, Ren Miao, Zhao Mengting, Zhong Qiuyuan, Ren Yuqi, Luo Pan, Ni Hong, Zhang Xiaoyu, Zhang Chen, Yuan Jing, Li Anan, Luo Minmin, Gong Hui, Luo Qingming, A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex. Nature Neuroscience, 2019, 22:1357-1370.
21. Luo Pan, Li Anan, Zheng Yanxiao, Han Yutong, Tian Jiaojiao, Xu Zhengchao, Gong Hui, Li Xiangning*, Whole Brain Mapping of Long-Range Direct Input to Glutamatergic and GABAergic Neurons in Motor Cortex. Frontiers in Neuroanatomy, 2019, 13:44.
22. Li Xiangning#, Yu Bin#, Sun Qingtao, Zhang Yalun, Ren Miao, Zhang Xiaoyan, Li Anan, Yuan Jing, Madisen L., Luo Qingming, Zeng Hongkui, Gong Hui, Qiu Zilong, Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons. PNAS, 2018, 115(2): 415-420.
招生专业：
生物医学工程、生物学、化学等相关专业
联系方式：lixiangning@hainanu.edu.cn
