
海南大学生物医学工程教授,博士生导师。入选国家高层次人才计划。2013年获得华中科技大学生物医学工程专业博士学位(湖北省优秀博士学位论文)。2013-2015年先后在美国威斯康辛大学麦迪逊分校与美国哈佛医学院麻省总医院进行博士后研究;2018年3月华中科技大学教授;2025年4月海南大学生物医学工程学院教授。在Science Advances, PNAS、Advanced Science、Biosensors & Bioelectronics、Theranostics等期刊上发表SCI论文50余篇。获得授权中国发明专利7项。目前研究方向:阿尔茨海默病的早期超灵敏检测与防治,包括:1、阿尔茨海默病超灵敏检测方法(涉及单克隆抗体筛选)、传感器件、微创采样的研发;2、外泌体囊泡递送系统;3、肠道菌群与阿尔茨海默病的发病机制;4、阿尔茨海默病病理蛋白与炎症、脂质关系。
代表性论文(链接:https://orcid.org/0000-0002-6226-5800)
1. Du Xuewei, Liu Ni, Zhang Taoping, Yang Changwen, Luo Haiming*. Size-Tailored Nanoparticle-Antibody Conjugates Overcome Hepatic Sequestration in Alzheimer's Disease Treatment. Proceedings of the National Academy of Sciences of the United States of America, 2026
2. Du Xuewei, Zhang Taoping, Wan Zhongzhong, Zhang Wanxue, Yan Bo, Zhang Tao, Su Ying, Wang Gaiqing, Zhang Liding*, Luo Haiming*. Reagentless, Wash-Free Multiplexed Analysis of Plasma Biomarkers for Alzheimer’s Disease Diagnosis via an Antibody-Based Molecular Pendulum. ACS Sensors, 2026
3. Zhang Liding, Yang Changwen, Yao Qian, Du Xuewei, Ding Shuai, Shi Yaoqiang, Sheng Can, Wang Ming, Han Ying, Luo Haiming*. Machine Learning-Enhanced Ultrasensitive Immuno-CRISPR Array Facilitates Early Diagnosis of Alzheimer's Disease by Detecting Multiple Plasma Biomarkers. Advanced Science, 2026: e75983
4. Chen Xiaoqian, Wang Haojie, Zhou Minxin, Lin Qiwen, Guo Yuyang, Zhang Weiye, Sun Yuhan, Li Zhi-Ming*, Luo Haiming*, Wang Rui*. HAAC Ligation-Enabled Hierarchical Assembly: Deciphering the Synergy of α-Hydroxyl Aldehydes and 2-Aminooxazoles. Journal of the American Chemical Society, 2026, 148(14): 14991-15001
5. Xie Jun, Cao Kai, Liu Luman, Zhang Liding, Yang Ying, Gong Hui, Luo Haiming*. Mn3O4 nanozyme-based anti-inflammatory therapy modulates microglial phenotype by downregulating TLR4/NOX2 expression and further alleviates Alzheimer's disease pathology. Theranostics, 2025, 15(15): 7467-7488
6. Zhang Liding, Du Xuewei, Yang Changwen, Gong Hui, Zhang Min, Han Ying*, Luo Haiming*. Ultrasensitive CRISPR-based biosensing platform for early diagnosis of Alzheimer's disease by simultaneous detection of plasma Aβ and hyperphosphorylated tau. Sensors and Actuators B: Chemical, 2025, 443: 138239
7. Wang Huide, Qiu Meng, Wang Chen, Zhang Liding, Fan Ning, Chen Zhi, Liu Yi, Li Tianzhong, Wang Ziqian, Zhu Yihan, Zhang Yule, Tian Xilin, Wang Yun, Yang Mingmin, Fan Dianyuan, Luo Qingming, Jiang Ke, Luo Haiming*, Zhang Han*. Light-Triggered Graphene/Black Phosphorus Heterostructure FET Platform for Ultrasensitive Detection of Alzheimer's Disease Biomarkers at the Zeptomole Level. Research (Wash D C), 2025, 8: 0772
8. Hu Shun, Zhang Liding, Su Ying, Liang Xiaohan, Yang Jie, Luo Qingming, Luo Haiming*. Sensitive detection of multiple blood biomarkers via immunomagnetic exosomal PCR for the diagnosis of Alzheimer’s disease. Science Advances. 2024, 10(13): eabm3088.
9. Zhang Liding, Cao Kai, Su Ying, Hu Shun, Liang Xiaohan, Luo Qingming, Luo Haiming*. Colorimetric and surface-enhanced Raman scattering dual-mode magnetic immunosensor for ultrasensitive detection of blood phosphorylated tau in Alzheimer's disease. Biosensor and Bioelectronics, 2023; 222:114935.
10. Hu Shun, Yang Changwen, Li Yanqing, Luo Qingming, Luo Haiming*. Nanozyme sensor array based on manganese dioxide for the distinction between multiple amyloid β peptides and their dynamic aggregation process. Biosensor and Bioelectronics. 2022,199: 113881
11. Hu Shun, Yang Changwen, Luo Haiming*. Current trends in blood biomarker detection and imaging for Alzheimer's disease. Biosensor and Bioelectronics. 2022, 210: 114278
12. Liu Ni, Liang Xiaohan, Yang Changwen, Hu Shun, Luo Qingming, Luo Haiming*. Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism. Theranostics. 2022, 12: 6646-6664
授权发明专利
1、骆海明;张立定;宋兆睿;分泌抗217位点苏氨酸磷酸化tau单克隆抗体的杂交瘤细胞株; 20251216,中国,专利号:ZL202411656298.1 已转让
2、骆海明;张立定;分泌人淀粉样蛋白-β单克隆抗体的杂交瘤细胞株及其应用;20230505,中国,专利号:ZL202011227808.5
3、骆海明;谢君;一种参与396,404位点丝氨酸磷酸化tau蛋白聚集mRNA的筛选方法及其应用;20250304,中国,专利号:ZL202510246483.1
4、骆海明;刘妮;胡顺;曹凯;一种用于清除β-淀粉样蛋白的特异性捕获载体及其应用;20220520,中国,专利号:ZL202110345476.9
5、骆海明;刘妮;胡顺;曹凯;杨昌文;纳米材料用于制备鼻腔纳米制剂脑靶向递送肠道药物应用;20220916,中国,专利号:ZL202110718344.6
6、骆海明;张立定;李艳青;牛是琦;一种用于阿尔茨海默病诊疗一体化的多功能的纳米粒子;20230526,中国,专利号:ZL202110518125.3
7、骆海明;郭云香;基于Transformer多翻译模型的分子表征及药物筛选方法;20240606;中国,专利号:ZL202410731811.2
8、骆海明;张立定;分泌抗丝氨酸磷酸化tau蛋白单克隆抗体的杂交瘤细胞株;20221014,中国,专利号:ZL202110067436.2
9、骆海明;王浩杰;一种荧光比率探针及其开发方法和应用;20240924;中国,专利号:ZL202411332189.4
10、骆海明;张立定;用于检测人淀粉样蛋白-β双抗夹心ELISA检测试剂盒;20220329,中国,专利号:202011227418.8
11、骆海明;骆清铭;张立定;用于检测人淀粉样蛋白-β的胶体金免疫层析试纸及其制备;20220325,中国,专利号:202110067679.6
学术兼职
担任中国研究型医院学会神经再生与修复专业委员会常务委员及阿尔兹海默病与生物标志物学组组长(202404-202903)、中国光学学会第四届生物医学光子学专业委员会常务委员(202411-202910)、白求恩精神研究会医学人文分会第二届理事会常务理事(202411-202910)、第三届生物医学工程学会生物医学光子学分会青年委员。担任Scientific Reports(2024年6月至今)、Experimental and Therapeutic Medicine(2022至今)期刊编委。以客座编辑在Biosensor、Frontiers in Cellular Neuroscience、Journal of Bio-X Research期刊各主办特刊1期。
招生需求
招收生物、医学、生物医学工程及相关专业的硕士生和博士生3-5人,博士后人和预聘教师。
联系方式:hemluo@hainanu.edu.cn