骆海明，海南大学生物医学工程教授，博士生导师。入选国家高层次人才计划、湖北省百人计划。2013年获得华中科技大学生物医学工程专业博士学位（湖北省优秀博士学位论文）。2013/10-2015/10年美国威斯康辛大学麦迪逊分校博士后；2015/10-2018/03年美国哈佛医学院麻省总医院博士后；华中科技大学教授（2018.04）；2024年6月海南大学生物医学工程学院教授。在Science Advances, PNAS、Clinical Cancer Research、Journal of Nuclear Medicine、Biosensors & Bioelectronics、Theranostics、Journal of Nanobiotechnology等期刊上发表SCI论文20多篇。获得授权中国发明专利7项。目前研究方向：阿尔茨海默病的早期超灵敏检测与防治
阿尔茨海默病方向代表性论文（*为通讯作者）
1. Hu Shun, Zhang Liding, Su Ying, Liang Xiaohan, Yang Jie, Luo Qingming, Luo Haiming*. Sensitive detection of multiple blood biomarkers via immunomagnetic exosomal PCR for the diagnosis of Alzheimer’s disease. Science Advances. 2024, 10(13):eabm3088.
2. Zhang Liding, Cao Kai, Su Ying, Hu Shun, Liang Xiaohan, Luo Qingming, Luo Haiming*. Colorimetric and surface-enhanced Raman scattering dual-mode magnetic immunosensor for ultrasensitive detection of blood phosphorylated tau in Alzheimer's disease. Biosensor and Bioelectronics, 2023;222:114935.
3. Hu Shun, Yang Changwen, Li Yanqing, Luo Qingming, Luo Haiming*. Nanozyme sensor array based on manganese dioxide for the distinction between multiple amyloid β peptides and their dynamic aggregation process. Biosensor and Bioelectronics. 2022,199:113881
4. Zhang Liding, Du Xuewei, Su Ying, Niu Shiqi, Li Yanqing, Liang Xiaohan, Luo Haiming*. Quantitative assessment of AD markers using naked eyes: point-of-care testing with paper-based lateral flow immunoassay. Journal of Nanobiotechnology. 2021, 19(1):366
5. Hu Shun, Yang Changwen, Luo Haiming*. Current trends in blood biomarker detection and imaging for Alzheimer's disease. Biosensor and Bioelectronics. 2022, 210:114278
6. Zhang Liding, Su Ying, Liang Xiaohan, Cao Kai, Luo Qingming, Luo Haiming*. Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer's disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assays. Nano Research. 2023;16(5):7459-7469
7. Zhang Liding, Cao Kai, Xie Jun, Liang Xiaohan, Gong Hui, Luo Qingming*, Luo Haiming*. Aβ42 and ROS dual-targeted multifunctional nanocomposite for combination therapy of Alzheimer's disease. Journal of Nanobiotechnology, 2024, 22(1):278
8. Liu Ni , Liang Xiaohan, Yang Changwen, Hu Shun, Luo Qingming, Luo Haiming*. Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism. Theranostics. 2022, 12: 6646-6664
9. Liang Xiaohan, Luo Haiming*. Optical Tissue Clearing: Illuminating Brain Function and Dysfunction. Theranostics. 2021,11(7):3035-3051
10. Zhang Liding, Yang Changwen, Li Yanqing, Niu Shiqi, Liang Xiaohan, Zhang Zhihong, Luo Qingming, Luo Haiming*. Dynamic changes in the levels of amyloid-β42 species in the brain and periphery of APP/PS1 mice and their significance for Alzheimer's disease. Frontiers in Molecular Neuroscience. 2021, 14:723317
活体成像检测方向代表性文章
11. Luo Haiming#, Hernandez Reinier#, Hong Hao, Graves A Stephen, Yang Yunan, Christopher G England, Theuer P Charles, Nickles J Robert, Cai Weibo. Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry. Proceedings of the National Academy of Sciences, 2015, 112(41):12806-11.
12. Luo Haiming, Christopher G England, Shi Sixiang, Graves A Stephen, Hernandez Reinier, Liu Bai, Theuer P Charles, Wong C Hing, Nickles J Robert, Cai Weibo. Dual Targeting of Tissue Factor and CD105 for Preclinical PET Imaging of Pancreatic Cancer. Clinical Cancer Research, 2016, 22(15):3821-30.
13. Luo Haiming, Hong Hao, Slater R Michael, Graves A Stephen, Shi Sixiang, Yang Yunan, Nickles J Robert, Fan Frank, Cai Weibo. PET of c-Met in cancer with 64Cu-labeled Hepatocyte Growth Factor. Journal of Nuclear Medicine, 2015, 56(5):758-63.
14. Luo Haiming#, Christopher G England#, Graves A Stephen, Sun Haiyan, Liu Glenn, Nickles J Robert, Cai Weibo. PET of VEGFR2 in cancer with 64Cu-labeled ramucirumab. Journal of Nuclear Medicine, 2016, 57(2):285-90.
15. Luo Haiming*, Yang Changwen, Kuang Dong, Chan W. Annie*. Visualizing dynamic changes in PD-L1 expression in non-small-cell lung carcinoma with radiolabeled recombinant human PD1. European Journal of Nuclear Medicine and Molecular Imaging. 2022, 49(8):2735-2745 (IF 10.057)
16. Luo Haiming, Lu Lisen, Yang Fei, Wang Liang, Yang Xiaoquan, Luo Qingming, Zhang Zhihong. Nasopharyngeal Cancer-Specific Therapy Based on Fusion Peptide-Functionalized Lipid Nanoparticles. ACS Nano, 2014, 8(5):4334-47.
17. Luo Haiming*, Lu Lisen, Liu Ni, Li Qingqing, Yang Xiaoquan, Zhang Zhihong*. Curcumin loaded sub-30 nm targeting therapeutic lipid nanoparticles for synergistically blocking nasopharyngeal cancer growth and metastasis. Journal of Nanobiotechnology. 2021, 19(1):224. (IF 9.464)
18. Luo Haiming, England G Christopher, Goel Shreya, Graves A Stephen, Ai Fanrong, Liu Bai, Theuer P Charles, Wong C Hing, Nickles J Robert, Cai Weibo. ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment. Molecular Pharmaceutics, 2017, 14(5):1646-1655.
19. Luo Haiming#, Shi Jiyun#, Jin Honglin, Fan Di, Lu Lisen, Wang Fan, Zhang Zhihong. An (125)I-labeled octavalent peptide fluorescent nanoprobe fortumor-homing imaging in vivo. Biomaterials, 2012, 33(19):4842-50.
20. Luo Haiming, Yang Jie, Jin Honglin, Huang Chuan, Fu Jianwei, Yang Fei, Gong Hui, Zeng Shaoqun, Luo Qingming, Zhang Zhihong. Tetrameric Far-Red Fluorescent Protein as a Scaffold to Assemble an Octavalent Peptide Nanoprobe for Enhanced Tumor Targeting and Intracellular Uptake In Vivo. The FASEB Journal, 2011, 25(6):1865-1873.
授权发明专利
1、骆海明；张立定；用于检测人淀粉样蛋白-β双抗夹心ELISA检测试剂盒；20220329，中国，专利号：202011227418.8
2、骆海明；骆清铭；张立定；用于检测人淀粉样蛋白-β的胶体金免疫层析试纸及其制备；20220325，中国，专利号：202110067679.6
3、骆海明；刘妮；胡顺；曹凯；一种用于清除β-淀粉样蛋白的特异性捕获载体及其应用；20220520，中国，专利号：ZL202110345476.9
4、骆海明；张立定；分泌人淀粉样蛋白-β单克隆抗体的杂交瘤细胞株及其应用；20230505，中国，专利号：ZL202011227808.5
5、骆海明；张立定；分泌抗丝氨酸磷酸化tau蛋白单克隆抗体的杂交瘤细胞株；20221014，中国，专利号：ZL202110067436.2
6、骆海明；刘妮；胡顺；曹凯；杨昌文；纳米材料用于制备鼻腔纳米制剂脑靶向递送肠道药物应用；20220916，中国，专利号：ZL202110718344.6
7、骆海明；张立定；李艳青；牛是琦；一种用于阿尔茨海默病诊疗一体化的多功能的纳米粒子；20230526，中国，专利号：ZL202110518125.3
学术兼职
中国研究型医院学会神经再生与修复专业委员会常务委员、中国研究型医院学会神经再生与修复专业委员会阿尔茨海默病与生物标志物亚专业首席专家、第三届生物医学工程学会生物医学光子学分会青年委员，中国抗癌协会肿瘤精准治疗专业委员会委员
招生需求
招收生物、医学、生物医学工程及相关专业的硕士生和博士生2-3人，博士后和预聘教师。
联系方式：hemluo@hainanu.edu.cn
