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04 2020.05

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    彭星舟

彭星舟(博士) ,2018年毕业于德国波茨坦大学,获得材料学理学博士学位。2013年3月至2019年4月在德国亥姆霍兹联合会吉斯特哈特材料研究(Helmholtz-Zentrum Hereon)材料研究所从事聚缩肽生物可降解材料的研究。2019年6月入职海南大学,同期赴华中科技大学和武汉光电国家研究中心访问学习。自2019年起,加入海南大学并在华中科技大学及武汉光电国家研究中心进行访问研究。在纳米材料、肿瘤免疫治疗、智能材料设计等方面有深入研究,主持多个国家自然科学基金及海南省科研项目。

Peng Xingzhou (Ph.D.) earned his Doctor degree in Materials Science from the Potsdam University, Germany, in 2018. From March 2013 to April 2019, he conducted research on polyester-based biodegradable materials at the Helmholtz-Zentrum Hereon Institute for Materials Research in Germany. He joined Hainan University in June 2019, concurrently conducting visiting research at Huazhong University of Science and Technology and the Wuhan National Laboratory for Optoelectronics.. His research focuses on nanomaterials, tumor immunotherapy, and smart material design, and he has led multiple projects funded by the National Natural Science Foundation of China and Department of Science and Technology of Hainan Province.

   主要研究方向Research Areas

1)神经-免疫微环境调控机制与精准干预策略。

Neuro-Immune Microenvironment Regulation Mechanisms and Precision Intervention Strategies

2)免疫动态影像与纳米探针研发。

Development of Immunoimaging and Nanoprobes

3)器官特异性与深度浸润相关的肿瘤纳米诊疗平台。

Organ-Specific or Tumor-targeting Nanoplatforms for Deep Infiltration

4)智能刺激响应材料及其在免疫调控和肿瘤治疗中的应用。

Stimulus-Responsive Platforms and Their Applications in Immuno-regulation and Tumor Therapy

   学术论文(Publications): 

1、 Xingzhou Peng#, Junjie Wang#, Zihan Deng#, Jianshuang Wei, Changqiang Xie, Yan Wang, Jianlei Han, Zhengyu Chen, Jianghai Du, Zhihong Zhang*, NIR laser-activated phthalocyanine loaded lipid nanoparticles targeting M2 macrophage for improved photoacoustic imaging-guided photothermal therapy, Materials Today Bio, 2024, 28, 101209.

2、 Junjie Wang#, Xingzhou Peng# , Jianshuang Wei, Yanfeng Dai, Songlin Huang, Deqiang Deng, Zhan Fan, Yuehong Leng, Jing Ai, Zhenzhen Cai, Maosong Qiu, Shizhen Chen, Xiaoquan Yang*, Zhihong Zhang*, In situ phagocyte-mediated deep tumor penetration assisted by ApoA-1 mimetic peptide-modified silicasome, Nano Today, 2023(50),101864.

3、 Xingzhou Peng#, Junjie Wang#, Feifan Zhou, Qian Liu*, Zhihong Zhang*, Nanoparticle-based approaches to target the lymphatic system for antitumor treatment, Cellular and molecular life sciences, 2021, 78(12), 5139–5161.

4、 Xiaomin Ma, Yazhe Xiao, Shuyu Li, Jianghai Du, Junjie Wang, Xingzhou Peng*, Recent Advances in Supramolecular Systems for Precision Medicine: Structural Design, Functional Integration, and Clinical Translation Challenges, Pharmaceutics, 2025, 17(9), 1192

5、 Junjie Wang#, Yan Wang#, Zhengdong Li#, Changqiang Xie, Musammir Khan, Xingzhou Peng*, Fabiao Yu*, Triphenylamine-AIEgens photoactive materials for cancer theranostics, Chinese Chemical Letters, 2023, 108934.

6、 Junjie Wang, Jianshuang Wei, Yuehong Leng, Yanfeng Dai, Changqiang Xie, Zhihong Zhang, Mingqiang Zhu*, Xingzhou Peng*, Rational Design of High-Performance Hemithioindigo-Based Photoswitchable AIE Photosensitizer and Enabling Reversible Control Singlet Oxygen Generation, Biosensors-Basel, 2023, 13(3), 324.

7、 Changqiang Xie, Yan Wang, Zhenzhen Cai, Jianghai Du, Zhengyu Chen, Junjie Wang*, Xingzhou Peng*, MMAE-loaded PLGA nanomedicine with improved biosafety to achieve efficient antitumor treatment, 2023, 10.1142/S1793545823500244.

8、 Xingzhou Peng, Marc Behl, Pengfei Zhang, Magdalena Mazurek-Budzynska, Yakai Feng, Andreas Lendlein*, Synthesis of well-defined dihydroxy telechelics by (co)polymerization of morpholine-2,5-diones catalyzed by Sn(IV) alkoxide , Macromolecular bioscience,2018(12).

9、 Xingzhou Peng, Marc Behl, Pengfei Zhang, Magdalena Mazurek-Budzynska, Yakai Feng, Andreas Lendlein*,Synthesis and characterization of multiblock poly(ester-amide-urethane),MRS Advance,2017(47),2551-2559.

10、 Xingzhou Peng, Marc Behl, Pengfei Zhang, Magdalena Mazurek-Budzynska, Muhammad Yaser Razzaq, Andreas Lendlein*, Hexyl-modified morpholine-2,5- dione-based oligodepsipeptides with relatively low glass transition temperature,Polymer, 2016(105),318-326.

11、 陈政宇,马晓敏,王俊杰*,彭星舟*,负载S-亚硝基-N-乙酰青霉胺水凝胶的制备及其性能,精细化工,1-12[2025-10-28].

12、 Changcan Shi, Xingzhou Peng, Yakai Feng, Hydrogel Surface/Coating for Smart Drug Delivery and Medical Devices, Gels, 2024, 10(9), 592.

13、 Muhammad Usama, Musammir Khan*, Xingzhou Peng, Junjie Wang, Chitosan/graphene oxide based biocomposite dynamic films for enzyme-free biosensing application, Materials Science and Engineering:B, 2024, 310, 117766

14、 Pengfei Zhang, Marc Behl, Xingzhou Peng, Maria Balk, Andreas Lendlein*, Chemo-responsive shape-memory effect of rhodium-phosphine coordination polymer networks,Chemistry of materials,2019(31),5402-5407.

15、 Pengfei Zhang, Marc Behl, Xingzhou Peng, Muhammad Yasar Razzaq, Andreas Lendlein*, Ultrasonic cavitation induced shape-memory effect in porous polmer networks,Macromolecular rapid communication, 2016(23), 1897-1903

   授权专利

1、 一种基于功能化二氧化硅并携载诊疗试剂的纳米颗粒及其制备方法与应用,CN116019911B,已授权

2、 能缓释NO并负载抗癌药物的纳米药剂及其方法和应用,CN118304276B,已授权

3、 一种新型光诊疗的纳米制剂及其制备方法和应用,CN118304404B,已授权

4、 一种可注射软生物电极用水凝胶及其制备方法和应用,CN119925645B,已授权

Patent Granted:

1、 A functionalized silica-based nanoparticle loaded with diagnostic and therapeutic reagents, its preparation method, and application, CN116019911B, Granted

2、 A nano-drug delivery system capable of sustained-release NO and loaded with anticancer drugs, its method, and application, CN118304276B, Granted

3、 A novel photodiagnostic and therapeutic nanoparticle formulation, its preparation method, and application, CN118304404B, Granted

4、 An injectable soft bioelectrode hydrogel, its preparation method, and application, CN119925645B, Granted

   参与主持科研项目:

1)国家自然科学基金委地区项目:靶向与响应性仿生硅脂质体时序调控 TGF-β/AMSH 双通路治疗结直肠癌肝转移的效果与机制研究,主持,在研。

2)海南大学科研启动项目:研究一种多功能多模态的纳米平台适用于不同组织/器官,主持,2019-2024

3)海南省科技计划崖州湾科技城联合项目:提高海洋类药物在体生物利用度及抗肿瘤能力的方法研究,主持,2021-2023

4)华中科技大学武汉光电国家研究中心开放基金课题:基于荧光/光声双模态多功能介孔硅纳米探针的制备及肿瘤光热治疗研究,主持,2022-2024

5)海南省自然科学基金高层次人才项目:细胞介导的肿瘤深层浸润与光诊疗研究,主持,2023-2025

Research Projects:

1) National Natural Science Foundation of China Regional Project: Study on the Efficacy and Mechanism of Targeted and Responsive silicasome in Treating Liver Metastasis of Colorectal Cancer, Principal Investigator, Ongoing.

2) Hainan University Research Start-up Project: Development of a Multifunctional Multimodal Nanoplatform Applicable to Different Tissues/Organs, Principal Investigator, 2019-2024

3) Hainan Provincial Science and Technology Plan Yazhou Bay Science City Joint Project: Methods to Enhance the In Vivo Bioavailability and Antitumor Capability of Marine-Derived Drugs, Principal Investigator, 2021–2023

4) Open Fund Project, Wuhan National Research Center for Optoelectronics, Huazhong University of Science and Technology: Preparation and Photothermal Therapy Research of Fluorescence/Photoacoustic Dual-Modality Multifunctional Mesoporous Silicon Nanoprobes, Principal Investigator, 2022-2024

5) Hainan Provincial Natural Science Foundation High-Level Talent Project: Cell-Mediated Deep Tumor Invasion and Photo-Diagnosis/Therapy Research, Principal Investigator, 2023-2025

 招生方向与背景要求(Research Areas and Applicant Requirements):

欢迎生物材料、生物医学工程、组织工程、免疫学、神经生物学、药剂学、医学影像等相关专业的硕士、博士研究生申请。学生需具有扎实的专业基础和良好的科研素养,具备相关领域的实验或理论基础优先。

特别欢迎有志于从事交叉前沿(如免疫-材料-成像-治疗一体化)研究的复合型人才加入。实验室注重多学科融合,鼓励学生在材料学、生命科学和临床医学交叉领域开展创新研究。

We welcome applications from Master's and Ph.D. candidates with backgrounds in biomaterials, biomedical engineering, tissue engineering, immunology, neurobiology, pharmaceutics, medical imaging, and other related disciplines. Applicants are required to demonstrate a solid foundation in their respective fields and possess strong research aptitude. Prior experimental or theoretical experience in relevant areas is preferred.

We particularly encourage applications from interdisciplinary candidates interested in conducting cutting-edge research at the interface of multiple fields, such as integrated immuno-material-imaging-therapeutic platforms. Our laboratory emphasizes multidisciplinary integration and encourages students to pursue innovative research at the intersection of materials science, life sciences, and clinical medicine.

Contact info: pengxzh@hainanu.edu.cn

联系方式pengxzh@hainanu.edu.cn