郭东波(博士) ,副教授,博士生导师,海南省拔尖人才。2018年上海交通大学化学专业毕业,获理学博士学位,师从朱新远教授、张川教授。2018-2020年在华南理工大学从事博士后工作(合作导师:Prof. Song Qing Shi)。2021-2022年在澳门大学以濠江学者(博士后研究员)身份从事科研工作(合作导师:Prof. Zikang Tang, Prof. Songnan Qu)。2022年入职海南大学生物医学工程学院。
主要研究方向:
1)碳材料的结构与光学性能的研究;
2)金属铂创新药设计;
3)智能微纳水凝胶平台的构建。
Google scholar: https://scholar.google.com/citations?user=6LHksUQAAAAJ&hl=zh-CN&oi=ao
学术论文与专利:
1. Guo D#, Lei J#, Rong D#, Zhang T, Zhang B, Tang Z, Shen H-M*, Deng C-X*, and Qu S*, Photocatalytic Pt(IV)-Coordinated Carbon Dots for Precision Tumor Therapy, Adv. Sci., 2022, 2205106. (IF: 17.521)
2. Guo D, Huang Y,* Jin X,* Zhang C, Zhu X,* A redox-responsive, in-situ polymerized polyplatinum(IV)-coated gold nanorod as an amplifier of tumor accumulation for enhanced thermo-chemotherapy, Biomaterials, 2021, 266, 120400. (IF: 15.304)
3. Guo D, Xu S, Yasen W, Zhang C,* Shen J,* Huang Y, Chen D, Zhu X,* Tirapazamine-Embedded Polyplatinum(IV) Complex: A Prodrug Combo for Hypoxia-Activated Synergistic Chemotherapy, Biomater. Sci., 2020, 8, 694-701 (IF: 7.590)
4. Guo D, Xu S, Huang Y, Jiang H, Yasen W, Wang N, Su Y, Qian J, Li J, Zhang C,* Zhu X, Platinum(IV) complex-based two-in-one polyprodrug for a combinatorial chemo-photodynamic therapy, Biomaterials, 2018, 177, 67-77. (IF: 15.304)
5. Guo D, Xu S, Wang N, Jiang H, Huang Y, Jin X, Xue B, Zhang C,* Zhu X,* Prodrug-Embedded Angiogenic Vessel-Targeting Nanoparticle: A Positive Feedback Amplifier in Hypoxia-Induced Chemo-Photo Therapy, Biomaterials, 2017, 144, 188-198. (IF: 15.304)
6. Yuan Y#, Xie B#, Guo D#, Liu C, Jiang G, Lai G, Zhang Y, Hu X, Wu Z, Zheng R, Huang L,* Identification of ALG3 as a Potential Prognostic Biomarker in Lung Adenocarcinoma, Heliyon, 2023, 9, e18065.
7. Yasen W,* Li B, Aini A, Li Z, Su Y, Zhou L,* Guo D, Qian Q, Chen D, Zhu X, Dong R,* Visible Light-Guided Gene Delivery with Nonviral Supramolecular Block Copolymer Vectors, ACS Appl. Mater. Interfaces, 2023, doi: 10.1021/acsami.3c0617 0. (IF: 10.383)
8. Jiang H, Guo D, Chen D, Wu Y, Jin X,* Zhu X,. A new insight into the reversal of multidrug resistance in cancer by nanodrugs, Biomater. Sci., 2019, 7 (8), 3489-3496. (IF: 7.590)
9. Huang Y, Shen L,* Guo D, Yasen W, Wu Y, Su Y, Chen D, Qiu F,* Yan D, Zhu X,* A NIR-triggered gatekeeper of supramolecular conjugated unimicelles with two-photon absorption for controlled drug release, Chem. Commun., 2019,55, 6735-6738. (IF:6.065)
10. Wang N, Jin X,* Guo D, Tong G, Zhu X.* Iron Chelation Nanoparticles with Delayed Saturation as an Effective Therapy for Parkinson Disease, Biomacromolecules, 2017, 18, 461-474. (IF: 6.978)
11. Jiang H, Chen D, Guo D, Wang N, Su Y, Jin X,* Tong G,* Zhu X., Zwitterionic gold nanorods: low toxicity and high photothermal efficacy for cancer therapy, Biomater. Sci., 2017, 5, 686-697. (IF: 7.590)
12. Chen D, Jiang H, Guo D, Yasen W, Ao J, Su Y, Pan D, Jin X,* Zhu X,. Anti-biofouling therapeutic nanoparticles with removable shell and highly efficient internalization by cancer cells, Biomater. Sci., 2019, 7, 336-346. (IF: 7.590)
13. Chen D, Huang Y, Jiang H, Yasen W, Guo D, Su Y, Xue B, Jin X,* Zhu X,. Fabrication of Activity-Reporting Glucose Oxidase Nanocapsules with Oxygen-Independent Fluorescence Variation. ACS Appl. Mater. Interfaces, 2018, 10, 26005-26015. (IF: 10.383)
14. Huang Y, Qiu F,* Chen D, Shen L, Xu S, Guo D, Su Y, Yan D, * Zhu X,* Color-Convertible, Unimolecular, Micelle-Based, Activatable Fluorescent Probe for Tumor-Specific Detection and Imaging In Vitro and In Vivo, Small, 2017, 13, 1604062. (IF: 15.151)
15. Yasen W, Dong R, Zhou L, Huang Y, Guo D, Chen D, Li C, Aini A, Zhu X,* Supramolecular block copolymers for gene delivery: Enhancement of transfection efficacy by charge regulation, Chem. Commun., 2017, 53, 12782-12785. (IF: 6.065)
专利:
1. 四价顺铂类前药与生物还原性药物联用的用途,ZL201810412121.5(授权)
2. 一种乏氧响应性壳聚糖药物载体及其制备方法与应用, ZL201911103912.0(授权)
3. 一种光化疗铂类前药及其制备方法、应用,ZL201710534634.9(授权)
4. 一种壳聚糖载药系统及其制备方法与应用,ZL202010053537.X(授权)
5. LINC01272在制备肿瘤检测试剂和/或治疗药物中的应用,ZL20201004588.6(授权)
6. 一种含磷阻燃聚芳酯及其制备方法,ZL201210158016.6 (授权)
主持科研项目:
1. 国家自然科学基金项目(52362006),2024-2027。
2. 国家自然科学基金项目(52203160),2023-2025。
3. 海南大学高层次人才科研启动基金(RZ2200001339),2022-2027。
4. 东莞市社会科技发展(重点)项目(2020507163160),2021-2023。
5. 广东省基础与应用基础研究基金联合基金青年基金项目(2019A1515111055),2020-2022。
6. 博士后科学基金项目,面上项目(一等),2018M640780,2018-2020。
招生需求:
招收生物医学工程、化学、材料、生物等相关专业的2-3名硕博研究生、博士后。
联系方式: dongboguo@hainanu.edu.cn