宋文（博士），副教授，2019年获武汉大学高分子化学与物理专业博士学位。同年进入武汉科技大学化学工程与技术博士后流动站做博士后工作研究。2022年12月加入海南大学生物医学工程学院。主要研究方向集中在纳米诊疗体系的构建及其在肿瘤免疫治疗中的应用。
主持科研项目:
1. 国家自然科学基金青年科学基金项目，202101-202312，30万，在研，主持
2. 国家自然科学基金地区科学基金项目，202401-202712，31万，在研，主持
3. 中国博士后科学基金 67 批面上资助二等，202009-202206，8万，已结题，主持
4. 国家自然科学基金面上项目，201901-202212，59 万，在研，参加
代表论文：
1. Song, W‡.; Song, S. J‡.; kuang, j‡.; Yang, H.; Yu, T.; Yang, F.; Wan, T.; Xu, Y.; Wei, S. T.; Li, M. X.; Xiong, Y*.; Zhou, Y*.; Qiu, W. X.*. Activating Innate Immunity by a STING Signal Amplifier for Local and Systemic Immunotherapy. ACS Nano 2022. 16, 15977-15993. (IF=18.027)
2. Song, W‡.; Hu, J.-J‡.; Song, S.-J‡.; Xu, Y.; Yang, H.; Yang, F.; Zhou, Y.; Yu, T.; Qiu, W.-X*., Aptamer-Gold Nanocage Composite for Photoactivated Immunotherapy. ACS Appl. Mater. Interfaces 2022. 14, 42931-42939. (IF=10.383)
3. Song, W‡.; Yang, F‡.; Yang, H‡.; Xu, Y.; Song, S. J.; Meng, Y.; Wei, S. T.; Wan, T.; Zhou, Y.; Zhou, B.; kuang, j.; Yu, T.; Qiu, W. X.*. Enhanced Immunotherapy Based on Combining Pro-Phagocytosis and Anti-Phagocytosis Checkpoints for Tumor Eradication. J. Med. Chem. 2022. 65, 14832-14842. (IF=8.039)
4. Chen, A‡.; Yang, F‡.; Kuang, J.; Xiong, Y.; Mi, B. B.; Zhou, Y.; Hu, J. J.; Song, S. J.; Wan, T.; Wan, Z. Z.; Huang, H. Y.; Li, X. R.; Song, W*.; Qiu, W. X*., A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment. ACS Appl. Mater. Interfaces 2021, 13, 45335-45345. (IF=10.383)
5. Song, W.; Kuang, J.; Li, C. X.; Zhang, M.; Zheng, D.; Zeng, X.; Liu, C*.; Zhang, X. Z*., Enhanced Immunotherapy Based on Photodynamic Therapy for Both Primary and Lung Metastasis Tumor Eradication. ACS Nano 2018, 12, 1978-1989. (IF=18.027 ESI Highly Cited Paper)
6. Kuang, J‡.; Song, W‡.; Yin, J.; Zeng, X.; Han, S.; Zhao, Y.-P.; Tao, J.; Liu, C.-J*.; He, X.-H*.; Zhang, X.-Z., iRGD Modified Chemo-immunotherapeutic Nanoparticles for Enhanced Immunotherapy against Glioblastoma. Adv. Funct. Mater. 2018, 28, 1800025. (IF=19.924)
招生需求：
招收生物医学工程、化学、材料学等相关专业研究生
联系方式：songwen@hainanu.edu.cn
Education & Professional Experience
Ph.D. Polymer Chemistry and Physics, Wuhan University (2019)
Postdoctoral Research, Postdoctoral Station of Chemical Engineering and Technology, Wuhan University of Science and Technology (2019)
Associate Professor, School of Biomedical Engineering, Hainan University (Dec 2022 – Present)
Research Focus
• Construction and Application of Antitumor Drug Carriers
• Efficacy Evaluation and Imaging of Tumor Immunotherapy
• Regulation and Application of Cellular Metabolism
Selected publications
1. Fu, Z.; Cui, X.; Liu, S.; Gao, L.; Sun, Y.; Chen, Y.; Li, M.; Fan, Y.; Kuang, J.; Song, W*.; Zhou, F*. Photo-Empowered Macrophage-Based Drug Delivery System Overcomes Motility Suppression and Significantly Enhances Deep Tumor Drug Delivery. Adv Sci 2025, e15349.
2. Yuan, L.; Yang, L.; Song, W.; Song, H.; Hu, J.-J*.; Lou, X*.; Xia, F.; Yoon, J. Photochemical Generation of Peroxynitrite: Concurrent Inhibition of Glycolysis and Glutamine Metabolism for Enhanced Metabolic Therapy. J Am Chem Soc 2025, 147 (36), 32610-32624.
3. Liu, S.; Sun, Y.; Yan, D*.; Song, W.; Fu, J.; Wang, S.; Yang, T.; Zhu, J.; Zhu, D.; Wang, D*.; Zhou, F*.; Tang, B. Z. A relay-type innate immunity activation strategy involving water-soluble NIR-II AIEgen for boosted tumor photo-immunotherapy. Theranostics 2024, 14 (12), 4667-4682.
4. Hu, J. J.; Yuan, L.; Zhang, Y.; Kuang, J.; Song, W.; Lou, X*.; Xia, F.; Yoon, J*. Photo-Controlled Calcium Overload from Endogenous Sources for Tumor Therapy. Angew Chem Int Ed Engl 2024, 63 (9), e202317578.
5. Fu, Z.; Feng, M.; Wu, J.; Liu, B.; Fu, J.; Song, W*. Photodynamic Therapy Synergizes CD47 Blockade Strategy for Enhanced Antitumor Therapy. Mol Pharmaceutics 2024, 21 (8), 3897-3908.
Selected publications before HNU
1. Song, W.; Yang, F.; Yang, H.; Xu, Y.; Song, S. J.; Meng, Y.; Wei, S. T.; Wan, T.; Zhou, Y.; Zhou, B.; Kuang, J*.; Yu, T*.; Qiu, W. X*. Enhanced Immunotherapy Based on Combining the Pro-phagocytosis and Anti-phagocytosis Checkpoint Blockade for Tumor Eradication. J Med Chem 2022, 65 (21), 14832-14842.
2. Song, W.; Song, S. J.; Kuang, J.; Yang, H.; Yu, T.; Yang, F.; Wan, T.; Xu, Y.; Wei, S. T.; Li, M. X.; Xiong, Y*.; Zhou, Y*.; Qiu, W. X*. Activating Innate Immunity by a STING Signal Amplifier for Local and Systemic Immunotherapy. ACS Nano 2022, 16 (10), 15977-15993.
3. Song, W.; Hu, J. J.; Song, S. J.; Xu, Y.; Yang, H.; Yang, F.; Zhou, Y*.; Yu, T*.; Qiu, W. X*. Aptamer-Gold Nanocage Composite for Photoactivated Immunotherapy. ACS Appl Mater Interfaces 2022, 14 (38), 42931-42939.
4. Chen, A.; Yang, F.; Kuang, J.; Xiong, Y.; Mi, B. B.; Zhou, Y.; Hu, J. J.; Song, S. J.; Wan, T.; Wan, Z. Z.; Huang, H. Y.; Li, X. R.; Song, W*.; Qiu, W. X*. A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment. ACS Appl Mater Interfaces 2021, 13 (38), 45335-45345.
5. Zheng, D. W.; Gao, F.; Cheng, Q.; Bao, P.; Dong, X.; Fan, J. X.; Song, W.; Zeng, X.; Cheng, S. X.; Zhang, X. Z*. A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy. Nat Commun 2020, 11 (1), 1985.
6. Zheng, D. W.; Hong, S.; Zhang, Q. L.; Dong, X.; Pan, P.; Song, W. F.; Song, W.; Cheng, S. X.; Zhang, X. Z*. Controllable gelation of artificial extracellular matrix for altering mass transport and improving cancer therapies. Nat Commun 2020, 11 (1), 4907.
7. Liu, W. L.; Zou, M. Z.; Liu, T.; Zeng, J. Y.; Li, X.; Yu, W. Y.; Li, C. X.; Ye, J. J.; Song, W.; Feng, J*.; Zhang, X. Z*. Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells. Nat Commun 2019, 10 (1), 3199.
8. Zhang, C.; Zhang, L.; Wu, W.; Gao, F.; Li, R. Q.; Song, W.; Zhuang, Z. N.; Liu, C. J.; Zhang, X. Z*. Artificial Super Neutrophils for Inflammation Targeting and HClO Generation against Tumors and Infections. Adv Mater 2019, 31 (19), e1901179.
9. Kuang, J.; Song, W.; Yin, J.; Zeng, X.; Han, S.; Zhao, Y. P.; Tao, J.; Liu, C. J*.; He, X. H*.; Zhang, X. Z. iRGD Modified Chemo-immunotherapeutic Nanoparticles for Enhanced Immunotherapy against Glioblastoma. Adv Funct Mater 2018, 28 (17), 1800025.
10. Song, W.; Kuang, J.; Li, C. X.; Zhang, M.; Zheng, D.; Zeng, X.; Liu, C*.; Zhang, X. Z*. Enhanced Immunotherapy Based on Photodynamic Therapy for Both Primary and Lung Metastasis Tumor Eradication. ACS Nano 2018, 12 (2), 1978-1989.
Email: songwen@hainanu.edu.cn
