秦天依(博士)，副研究员，硕、博导师，海南省拔尖人才，海南省首批优秀青年项目获得者，三亚崖州湾科技城D类人才。
研究方向：
1) 分子、超分子荧光探针：设计及构效揭示；
2) 疾病标志物体外即时检测、体内靶向成像；
3) 环境、食品中致病性有害物检测。
招生需求：
欢迎具有分析化学、有机化学、智能分子工程、生物技术工程、物理化学、计算化学等相关专业背景的同学加入
欢迎具备荧光探针、蛋白配体互作、荧光成像、超分子化学等研究经验的博士后加入（https://bme.hainanu.edu.cn/info/1058/7631.htm）
联系方式：qintianyi@hainanu.edu.cn
教育研究经历：
2008-2012：南开大学，化学学院，材料化学，本科（导师：杨化滨）
2012-2017：中国科学院理化技术研究所，有机化学，博士（导师：李嫕）
2017-2019：深圳大学，材料学院，博士后（合作导师：刘斌、王雷）
2020-2022：华南农业大学，植物保护学院，博士后（合作导师：徐汉虹）
2023-至今：海南大学，生物医学工程学院，分子靶向成像团队（PI：朱明强教授）
论文/Publications：
Google scholar: https://scholar.google.com/citations?user=9hYA-KgAAAAJ&hl=zh-CN&oi=ao
(23) Yuting Luo, Xiaoyi Fu, Xinfeng Du*, Xinjie Zhu, Zhongyong Xu, Zhaohui Wang, Ya-Long Wang*, Tianyi Qin*, Bin Liu. Albumin-based host-guest ratiometric fluorescent sensor array for discrimination of testosterone, estrone, and estradiol. Analytical Chemistry, 2026, under review.
(22) Zhenyu Zhang; Junxin Yi; Zhang Lin; Zhaohui Wang; Ya-Long Wang*; Xinfeng Du*; Tianyi Qin*. Non-conjugated alkyl chain in ionic molecular rotor fluorophores: an effective modulating moiety for Amyloid-β probes. Analytical Chemistry, 2026, in revision.
(21) Caiqiang Liao, Xinfeng Du, Zhang Lin, Yuting Luo, Yangyang Yu, Zhaohui Wang, Jun Peng, Zhongyong Xu, Xianwen Liang, Zhilong Wu, Ya-Long Wang*, Tianyi Qin*, Bin Liu, Ming-Qiang Zhu. N‐Alkyl Extension in Ionic Molecular Rotors: Facile Tuning of Sensing Modes for Albumin‐Based Host‐Guest Fluorescent Sensors. Angewandte Chemie International Edition, 2026, e1330357.
(20) Linhui Peng, Yuting Luo, Zhiqing Xun *, Zhongyong Xu, Taoyuze Lv, Xinrong Du, Zhaohui Wang, Ya-Long Wang *, Tianyi Qin *, Bin Liu, and Ming-Qiang Zhu. A Ratiometric Fluorescent Probe with Distinct Response to Aflatoxin B1 and B2a: Probe Design, Bioimaging, and Quantification. Food Chemistry, 2026, in revision.
(19) Zhongyong Xu, Caiqiang Liao, Immanuel David Charles, Tianyi Qin*, Bin Liu*. A chalcone molecular switch with dual-state-emission for ratiometric tracking of hydrogen peroxide. Chemical Communications, 2025, 61(80), 15650-15653.
(18) Yuting Luo, Linhui Peng, Zhang Lin, Zhiqing Xun, Na Li, Naiyu Liu, Ya-Long Wang, Xinfeng Du, Tianyi Qin*, Bin Liu, Ming-Qiang Zhu. Engineered albumin host for ratiometric fluorescent indicator-displacement assays: distinguishing testosterone from estrone and estradiol. Chemical Engineering Journal, 2025, 167964.
(17) Ze-Jun Li, Zhen-Yu Zhang, Yao-Yuan Jiang, Yun-Miao Liu, Jian Wang, Ya-Long Wang*, Tian-Yi Qin*, Ming-Qiang Zhu*. Construction of High-Performance Wash-Free Aβ Probes Based on Amino Group Optimization and Amphiphilic Molecular Engineering Strategies. Analytical Chemistry, 2025, 97, 34, 18479–18489.
(16) Caiqiang Liao, Xianwen Liang, Tianyi Qin*, Xinfeng Du, Haoyan Xiong, Quan Chen, Cuizhen Lu, Zhongyang Zhang, Zhongyong Xu, Taoyuze Lv, Zhaohui Wang, Ya-L ong Wang, Bin Liu, Ming-Qiang Zhu. Regulating the hydrophobic part in amphiphilic triphenylamino-diarylethene fluorophores for ultrasensitive and portable detection of urinary albumin. Sensors and Actuators B: Chemical, 2025, 137592.
(15) Zhenyu Zhang, Zejun Li, Yinghao Tang, Tingting Hou, Liang Xu, Zhaohui Wang, Tianyi Qin*, Yalong Wang*, Mingqiang Zhu. Tailoring near-infrared amyloid-β probes with high-affinity and low background based on CN and amphipathic regulatory strategies and in vivo imaging of AD mice. Talanta, 2025, 281, 126858.
(14) Cuizhen Lu, Liang Xu, Yu Jiang, Caiqiang Liao, Yixin Li, Yinghao Tang, Zhongyong Xu, Xinfeng Du, Taoyuze Lv, Yalong Wang*, Tianyi Qin*, Bin Liu, Mingqiang Zhu. Sensitive and accurate monitoring of urinary albumin and point-of-care testing using a fluorescent probe with anti-interference capacity against exogenous drugs. Talanta, 2024, 279, 126575.
(13) Weihua Deng, Tianyi Qin*, Na Li, Zhongyong Xu, Lei Wang, Mingle Li, Xiaoqiang Chen, Shiwei Zhang, Bin Liu*, Xiaojun Peng, Flavonoid dyes with molecular packing-induced fluorochromism for ratiometric broad-spectrum detection of avermectins. Sensors and Actuators B: Chemical, 2024, 419, 136406.
(12) Cui-Zhen Lu, Cai-Yun Wang, Chao Song, Tianyi Qin*, Taoyuze Lv, Conghui Zeng, Shihong Chen, Zhongyong Xu, Zhiqing Xun*, Bin Liu*, Ya-Long Wang*, Ming-Qiang Zhu. A ratiometric fluorescent indicator-displacement assay for on-site determination and intracellular imaging of nitroxinil. Food Chemistry, 2024, 435, 137617.
(11) Chao Song, Conghui Zeng, Tianyi Qin*, Taoyuze Lv, Zhongyong Xu, Zhiqing Xun, Lei Wang, Xiaoqiang Chen, Bin Liu*, and Xiaojun Peng. A dual-state-emission chalcone-based supramolecular probe for ratiometric detection of penconazole in environmental samples. Chemical Engineering Journal, 2023, 143610.
Selected publications before HNU
(10) Tianyi Qin, Xiongfei Zhao, Chao Song, Taoyuze Lv, Shihong Chen, Zhiqing Xun, Zhongyong Xu, Zhixiang Zhang, Hanhong Xu, Chen Zhao, Bin Liu*, and Xiaojun Peng. A ratiometric supramolecular fluorescent probe for on-site determination of cyfluthrin in real food samples. Chemical Engineering Journal, 2023, 451, 139022.
(9) Tianhao Jia, Chunmei Pu, Tianyi Qin*, Bin Liu, Guangkai Yao, Zhiqing Xun, Bingfeng Wang, Yongqing Tian, Zhixiang Zhang*, Hanhong Xu*, Chen Zhao*. Azocalixarene-Based Supramolecular System for the Detection of Paraquat via an Improved Indicator Displacement Assay. Journal of Agricultural and Food Chemistry, 2022, 70(50), 15981–15989.
(8) Tianyi Qin, Xiongfei Zhao, Tianhao Jia, Xinfeng Du, Taoyuze Lv, Yongqing Tian, Zhixiang Zhang, Bin Liu*, Hanhong Xu*, and Chen Zhao*. A novel protein-based supramolecular recognition approach for ratiometric fluorescence detection of fipronil. Sensors and Actuators B: Chemical, 2022, 369, 132358.
(7) Tianyi Qin, Xiongfei Zhao, Taoyuze Lv, Guangkai Yao, Zhongyong Xu, Lei Wang, Chen Zhao*, Hanhong Xu*, Bin Liu*, and Xiaojun Peng. General method for pesticide recognition using albumin-based host-guest ensembles. ACS sensors, 2022, 7(7), 2020-2027.
(6) Xiongfei Zhao, Weidong Zheng, Tianyi Qin*, Xinfeng Du, Yanmei Lei, Taoyuze Lv, Mei Zhou, Zhongyong Xu, Lei Wang, Bin Liu*, and Xiaojun Peng. An anti-interference fluorescent probe for point-of-care diagnosis of albuminuria. Sensors and Actuators B: Chemical, 2022, 351, 130980.
(5) Tianyi Qin, Bin Liu*, Zhongyong Xu, Guangkai Yao, Hanhong Xu*, and Chen Zhao*. Flavonol-based small-molecule fluorescent probes. Sensors and Actuators B: Chemical, 2021, 129718.
(4) Tianyi Qin, Bin Liu*, Bing Du, Yingying Huang, Guangkai Yao, Zhiqing Xun, Hanhong Xu*, and Chen Zhao*. Solvatofluorochromic flavonoid dyes with enlarged transition dipole moments enable ratiometric detection of methanol in commercial biodiesel with improved sensitivities. Journal of Materials Chemistry C, 2020, 8(47), 16808-16814.
(3) Tianyi Qin, Bin Liu*, Yingying Huang, Kuan Yang, Kangning Zhu, Zijie Luo, Chengjun Pan, Lei Wang*. Ratiometric fluorescent monitoring of methanol in biodiesel by using an ESIPT-based flavonoid probe. Sensors and Actuators B: Chemical, 2018, 277, 484-491.
(2) Tianyi Qin, Bin Liu*, Kangning Zhu, Zijie Luo, Yingying Huang, Chengjun Pan, Lei Wang*. Organic fluorescent thermometers: Highlights from 2013 to 2017. TrAC Trends in Analytical Chemistry, 2018, 102, 259-271.
(1) Tianyi Qin, Xuying Li, Jinping Chen*, Yi Zeng, Tianjun Yu, Guoqiang Yang*, Yi Li*. Dendritic Ionic Liquids Based on Imidazolium‐Modified Poly (aryl ether) Dendrimers. Chemistry–An Asian Journal, 9(12), 3641-3649.
专利/Patents：
(1) 秦天依、陆翠珍、王亚龙，一种抗药物干扰的尿蛋白荧光探针及其制备方法和应用，CN202410807919.5，已授权
(2) 秦天依、廖才强、王亚龙，一种用于尿白蛋白快速检测的三苯胺-吡啶鎓盐荧光探针及其制备方法，CN202411911158.4，已授权
(3) 秦天依、彭琳慧、王亚龙，一种比率型荧光探针及其在区分检测黄曲霉毒素B1和黄曲霉毒素B2a中的应用，CN 202511827525.7，发明公开
科研项目/Research Projects：
1. 海南省重点研发项目(ZDYF2026SHFZ069)，2026.03~2029.03，主持，在研
2. 海南省自然科学基金-优秀青年基金(224YXQN414)，2024.03~2027.03，主持，在研。
3. 国家自然科学基金委-地区项目(22364012), B04，2024.01~2027.12，主持，在研。
4. 国家自然科学基金委-青年项目(32102243), C14，2022.01~2024.12，主持，结题。
5. 中国博士后基金会-面上项目(2021M691084), 2022.01~2023.12，主持，结题。
研究组成员：
在读：
2023级 博：张振宇
2024级 硕：易郡鑫、黄丽珍
2025级 硕：符小怡、董禹显
已毕业：
2025届 本 邓权海（海南海一信通科技有限公司）
2026届 本 熊浩言（新加坡国立大学 读硕）
2025届 硕 陆翠珍（宁波康龙化成）
2025届 硕 李益欣（）
2026届 硕 骆玉婷（）
2026届 硕 彭琳慧（）
2026届 硕 廖才强（西北农林科技大学 读博）
个人及指导学生获奖荣誉：
2024 陆翠珍 国家奖学金、海南大学2023-2024年度优秀研究生、海南大学大学生年度人物提名奖
2024 廖才强 海南大学科技创新先进个人
2025 廖才强 三亚崖州湾科技城第三届研究生学术年会汇报奖（二等）
2025 骆玉婷 三亚崖州湾科技城第三届研究生学术年会汇报奖（三等）
2025 张振宇 三亚崖州湾科技城第三届研究生学术年会汇报奖（三等）
2025 张振宇、李泽君、易郡鑫 第十届全国大学生生物医学工程创新设计竞赛 二等奖
2025 廖才强 国家奖学金、海南大学2024-2025学年优秀研究生、一等学业奖学金
2025 张振宇 国家奖学金、海南大学2024-2025学年优秀研究生、一等学业奖学金
2025 易郡鑫 一等学业奖学金
2025 骆玉婷 海南大学2024-2025学年优秀研究生
2025 骆玉婷 海南省生物医学工程学会“第一届生物医学工程研究生论坛”-优秀墙报奖
Name：
Tianyi Qin
Title：
Associate Professor
Education Background：
Ph.D. (Technical Institute of Physics and Chemistry, CAS)
B. Sc. (Nankai University)
Research：
Fluorescent probes, host-guest supramolecular probes, functional fluorescent dyes, point-of-care testing
Biography：
Dr. Tianyi Qin obtained his Ph.D. degree in organic chemistry from TIPC, CAS (2012-2017). Prior to joining HNU in 2023, Dr Qin worked as a post doc researcher at Shenzhen University (2017-2019) and South China Agricultural University (2020-2022), successively. He has been certificated as a Class-D talent of Hainan Province, a Class-D talent of Sanya Yazhou Bay Science and Technology City, and He received the first batch of Hainan Provincial Excellent Young Scientist Fund.
Dr. Qin’s research group is interested in performing extensive research on the development of new fluorescent probes and unveiling their structure-property relation in applications. The group’s objective is to achieve on-demand tuning the binding sites, sensing modes, and sensing properties in albumin-dye host-guest sensing systems. With this emphasis, his group approaches technological advancements from a variety of disciplines, covering fields of smart molecule, protein-ligand simulation, ratiometric probe design, POCT devices, and imaging applications.
Dr. Qin has published more than 40 articles (h-index: 22, citations 1600+) in renowned journals, such as Chemical Engineering Journal, ACS Sensors, Sensors and Actuators: B-Chemical, and Food Chemistry. For scanning more, please visit Google scholar: https://scholar.google.com/citations?user=9hYA-KgAAAAJ&hl=zh-CN&oi=ao.
Positions Available：
We are looking for graduate students with educational background of analytical chemistry, organic chemistry, smart molecule engineering, and biotechnological engineering. Postdoctoral Fellows with research background in fluorescent probe are highly welcome.
Email：
qintianyi@hainanu.edu.cn
Office Address：
Room B604, 7 Daxue Rd, Yazhou District, Sanya, Hainan Province, China
