张立定（博士），副研究员，2023年6月获得华中科技大学生物医学光子学专业博士学位。同年进入海南大学生物学博士后流动站做博士后工作研究。2025年9月加入海南大学生物医学工程学院。
主要研究方向：
1） 阿尔兹海默病早期诊断
2） 阿尔兹海默病分子标记与靶向治疗
科研项目：
1. 国家自然科学基金（青年科学基金）项目，202501-202712，30万，在研，主持
2. 海南省自然科学基金青年基金项目，202503-202702，6万，在研，主持
3. 中国博士后科学基金会第18批特别资助项目，202501-202509，18万，已结题，主持
4. 中国博士后科学基金会第75批面上项目，202409-202506，8万，已结题，主持
5. 国家资助博士后研究人员计划，202307-202506，24万，已结题，主持
6. 海南省博士后研究项目，202501-202612，15万/年，在研，主持
7. 海南省博士后面上项目，202401-202509，10万，已结题，主持
代表论文：
1. Liding Zhang†, Xuewei Du†, Changwen Yang, Hui Gong, Min Zhang, Ying Han*, Haiming Luo*. Ultrasensitive CRISPR-based biosensing platform for early diagnosis of Alzheimer's disease by simultaneous detection of plasma Aβ and hyperphosphorylated tau. Sensors and Actuators B: Chemical. 2025, 443: 138239.
2. Liding Zhang†, Kai Cao†, Jun Xie, Xiaohan Liang, Qingming Luo*, Haiming Luo*. Aβ42 and ROS Dual-targeted Multifunctional Nanocomposite for Combination Therapy of Alzheimer’s Disease. Journal of Nanobiotechnology. 2024; 22(1):278.
3. Liding Zhang†, Ying Su†, Xiaohan Liang, Kai Cao, Qingming Luo, Haiming Luo*. Ultrasensitive and point-of-care detection of plasma biomarker in Alzheimer's disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay. Nano Research. 2023; 16(5):7459-7469.
4. Liding Zhang, Kai Cao, Ying Su, Shun Hu, Xiaohan Liang, Qingming Luo, Haiming Luo*. Colorimetric and surface-enhanced Raman scattering dual-mode magnetic immunosensor for ultrasensitive detection of blood phosphorylated tau in Alzheimer's disease. Biosensors and Bioelectronics. 2023; 222:114935.
5. Liding Zhang†, Xuewei Du†, Ying Su†, Shiqi Niu, Yanqing Li, Xiaohan Liang, Haiming Luo*. Quantitative assessment of AD markers using naked eyes: point-of-care testing with paper-based lateral flow immunoassay. Journal of Nanobiotechnology. 2021; 19(1):366.
6. Liding Zhang, Changwen Yang, Yanqing Li, Shiqi Niu, Xiaohan Liang, Zhihong Zhang, Qingming Luo, Haiming Luo*. Dynamic changes in the levels of amyloid-β42 species in the brain and periphery of APP/PS1 mice and their significance for Alzheimer’s disease. Frontiers In Molecular Neuroscience. 2021; 14:723317.
7. Wensheng Qu†, Liding Zhang†, Xiaohan Liang, Zhiyuan Yu, Hao Huang, Jing Zhao, Yinping Guo, Xirui Zhou, Shabei Xu, Haiming Luo*, Xiang Luo*. Elevated Plasma Oligomeric Amyloid β-42 is Associated with Cognitive Impairments in Cerebral Small Vessel Disease. Biosensors. 2023,13(1):110.
8. Liding Zhang†, Xuewei Du†, Zhixin Chen, Congjie Chen, Nanxin Gong, Yihao Song, Yuzhu Song, Qinqin Han, Xueshan Xia, Haiming Luo*, Jinyang Zhang*. Instrument-Free and Visual Detection of Salmonella Based on the Magnetic Nanoparticles and Antibody-Probe Immunosensor. International Journal of Molecular Sciences. 2019,20 (18):4645.
9. Liding Zhang†, Qiujiang Wei†, Qinqin Han, Qiang Chen, Wenlin Tai, Jinyang Zhang*, Yuzhu Song*, Xueshan Xia*. Detection of Shigella in Milk and Clinical Samples by Magnetic Immunocaptured-Loop-Mediated Isothermal Amplification Assay. Frontiers in Microbiology. 2018,9:94.
10. Liding Zhang†, Xuewei Du†, Congjie Chen, Zhixin Chen, Li Zhang, Qinqin Han, Xueshan Xia*, Yuzhu Song*, Jinyang Zhang*. Development and Characterization of Double-antibody Sandwich ELISA for Detection of Zika Virus Infection. Viruses. 2018,10(11): 634.
授权专利：
1. 张金阳，张立定，石耀强，宋玉竹，夏雪山，韩芹芹，陈强。肺炎克雷伯杆菌的IC-PCR检测引物组及其应用。专利号：ZL201811342422.1
2. 张金阳，张立定，石耀强，宋玉竹，夏雪山。用于检测肺炎克雷伯杆菌的特异性抗体组及应用。专利号：ZL201810261060.7
3. 张金阳，张立定，陈志鑫，宋玉竹，夏雪山，杜雪薇。一种单克隆抗体及其应用。专利号：ZL201811342423.6
4. 骆海明，张立定。分泌人淀粉样蛋白-β单克隆抗体的杂交瘤细胞株及其应用。专利号：ZL202011227808.5。
5. 骆海明，张立定。用于检测人淀粉样蛋白-β双抗夹心ELISA检测试剂盒。专利号：ZL202011227418.8
6. 骆海明，骆清铭，张立定。一种用于检测人淀粉样蛋白-β的胶体金免疫层析试纸及其制备。专利号：ZL2021110067679.6
7. 骆海明，张立定，李艳青，牛是琦。二种分泌抗丝氨酸磷酸化tau蛋白单克隆抗体的杂交瘤细胞株。专利号：ZL202110067436.2
8. 骆海明，张立定，李艳青，牛是琦。一种用于阿尔茨海默病诊疗一体化的多功能的纳米粒子。专利号：ZL202110518125.3
招生需求：
招收生物、医学、生物医学工程及相关专业的硕士生
联系方式：lidingzhang@hainanu.edu.cn
